Field evaluation of a novel oral reservoir-targeted vaccine against Borrelia burgdorferi utilizing an inactivated whole-cell bacterial antigen expression vehicle

Blacklegged ticks ( Ixodes scapularis ) are the principal vector for Borrelia burgdorferi, among other infectious agents, in the northeastern, mid-Atlantic, and upper midwestern USA. White-footed mice ( Peromyscus leucopus ) are the primary and most competent reservoir host of B. burgdorferi in the...

Full description

Saved in:
Bibliographic Details
Published in:Experimental & applied acarology 2020-02, Vol.80 (2), p.257-268
Main Authors: Stafford, Kirby C., Williams, Scott C., van Oosterwijk, Jolieke G., Linske, Megan A., Zatechka, Steve, Richer, Luciana M., Molaei, Goudarz, Przybyszewski, Chris, Wikel, Stephen K.
Format: Article
Language:English
Subjects:
Animal Ecology
Animal Genetics and Genomics
Animal Systematics/Taxonomy/Biogeography
Antigens
Biomedical and Life Sciences
Borrelia burgdorferi
Entomology
Ixodes scapularis
Larvae
Life Sciences
Peromyscus leucopus
Properties (attributes)
Rodents
Ticks
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blacklegged ticks ( Ixodes scapularis ) are the principal vector for Borrelia burgdorferi, among other infectious agents, in the northeastern, mid-Atlantic, and upper midwestern USA. White-footed mice ( Peromyscus leucopus ) are the primary and most competent reservoir host of B. burgdorferi in the Northeast. Live reservoir-targeted vaccines (RTVs) to limit enzootic transmission of B. burgdorferi were previously developed and successfully evaluated in laboratory and controlled field trials. A novel, inactivated RTV was developed to minimize regulatory and market challenges facing previous RTVs based on live bacterial or viral vehicles. Thirty-two residential properties in Redding, Connecticut, participated in a field trial of an orally delivered, inactivated RTV efficacy study (2015–2016). During the two-year vaccination period, a significant decrease in the percentage of B. burgdorferi- infected I. scapularis larvae parasitizing P. leucopus was observed, as was a significant reduction in the percentage of infected P. leucopus on RTV-treated properties when compared to control properties. This novel inactivated RTV was effective in reducing numbers of B. burgdorferi -infected I. scapularis and B. burgdorferi -infected P. leucopus on properties where it was distributed.
ISSN:0168-8162
1572-9702
DOI:10.1007/s10493-019-00458-1