The role of diosgenin in diabetes and diabetic complications

•Diosgenin is a plant steroid that improves diabetes and its complications.•Diosgenin can effectively regulate the related targets and pathways of glycolipid metabolism, apoptosis, inflammation and oxidative stress to improve diabetes and its complications.•The pharmacokinetics and hypoglycemic effe...

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Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2020-04, Vol.198, p.105575-105575, Article 105575
Main Authors: Gan, Qingxia, Wang, Jin, Hu, Ju, Lou, Guanhua, Xiong, Haijun, Peng, Chengyi, Zheng, Song, Huang, Qinwan
Format: Article
Language:English
Subjects:
Biological activity
Cardiomyopathy
Diabetes
Diabetes mellitus
Diabetic complications
Diabetic neuropathy
Diosgenin
Eye diseases
Hyperglycemia
Liver diseases
Metabolic disorders
Metabolism
Multiple pathways
Multiple targets
Nephropathy
Vascular diseases
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Summary:•Diosgenin is a plant steroid that improves diabetes and its complications.•Diosgenin can effectively regulate the related targets and pathways of glycolipid metabolism, apoptosis, inflammation and oxidative stress to improve diabetes and its complications.•The pharmacokinetics and hypoglycemic effect of diosgenin are different under different conditions. Diabetes mellitus is a chronic and common metabolic disease that seriously endangers human health. Hyperglycemia and long-term metabolic disorders in diabetes will cause damage to the whole body tissues and organs, resulting in serious complications. Nowadays, drugs for treating diabetes on the market has strong side effects, new treatments thus are urgently needed. Natural therapy of natural ingredients is a promising avenue, this is because natural ingredients are safer and they also show strong activity in the treatment of diabetes. Diosgenin is such a very biologically active natural steroidal sapogenin. The research of diosgenin in the treatment of diabetes and its complications has been widely reported. This article reviews the effects of diosgenin through multiple targets and multiple pathways in diabetes and its complications which including diabetic nephropathy, diabetic liver disease, diabetic neuropathy, diabetic vascular disease, diabetic cardiomyopathy, diabetic reproductive dysfunction, and diabetic eye disease.
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2019.105575