Euterpe oleracea (Martius) Oil Reverses Testicular Alterations Caused after Cadmium Administration

Cadmium (Cd) is an environmental pollutant that induces reproductive toxicity by generating reactive oxygen species, which leads to oxidative stress. Euterpe oleracea fruits are known for being rich in oils containing triacylglycerol and phenolic compounds. They are considered as potent antioxidants...

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Bibliographic Details
Published in:Biological trace element research 2020-10, Vol.197 (2), p.555-570
Main Authors: Mouro, Viviane Gorete Silveira, de Melo, Fabiana Cristina Silveira Alves, Martins, Ana Luíza Pereira, de Lucca Moreira Gomes, Marcos, de Oliveira, Jerusa Maria, de Freitas, Mariella Bontempo Duca, Demuner, Antônio Jacinto, Leite, João Paulo Viana, da Matta, Sérgio Luis Pinto
Format: Article
Language:English
Subjects:
Antioxidants
Aqueous solutions
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cadmium
Cadmium chloride
Cell viability
Cytoplasm
Epithelium
Euterpe oleracea
Intoxication
Life Sciences
Manganese
Morphometry
Nuclei (cytology)
Nutrition
Oil
Oncology
Oxidative stress
Parenchyma
Phenolic compounds
Phenols
Pollutants
Reactive oxygen species
Reduction
Serum
Testes
Testosterone
Toxicity
Triglycerides
Zinc
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Summary:Cadmium (Cd) is an environmental pollutant that induces reproductive toxicity by generating reactive oxygen species, which leads to oxidative stress. Euterpe oleracea fruits are known for being rich in oils containing triacylglycerol and phenolic compounds. They are considered as potent antioxidants to be used to counteract Cd effects within the testis. In the present study, adult males Swiss mice were treated with CdCl 2 aqueous solution (4.28 mg/kg) by gavage for 7 days. The experimental groups were treated with Euterpe oleracea oil at the doses of 50, 100, and 150 mg/kg, for 42 days. The results showed that Cd intoxication led to increased tubular pathologies, such as reduction in epithelium height and area thus increasing both luminal diameter and tubule-epithelium ratio. Besides, Leydig cell’s morphometry indicated reduction in nucleus and cytoplasm volumes of this cell type, which were recovered after E. oleracea oil intake. In addition, serum testosterone levels, testicular Mn and Zn concentrations, SOD and CAT activity, and germ cell viability increased after oil intake. Therefore, E. oleracea oil showed a regenerative effect in the testicular parenchyma negatively affected by Cd, mainly in the animals that received the highest oil concentration (150 mg/kg).
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-019-02004-x