Recent progress in neuronal intranuclear inclusion disease: a review of the literature

Objective To summarize the current understanding of neuronal intranuclear inclusion disease (NIID) and improve the understanding of the physician about this condition. Methods We searched PubMed with keywords related to NIID and selected publications which seemed appropriate. We analyzed its clinica...

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Bibliographic Details
Published in:Neurological sciences 2020-05, Vol.41 (5), p.1019-1025
Main Authors: Raza, Hafiz Khuram, Singh, Sandeep, Rai, Pabitra, Chansysouphanthong, Thitsavanh, Amir, Arooj, Cui, Guiyun, Song, Wenjing, Bao, Lei, Zhou, Su, Shi, Hongjuan, Chen, Hao
Format: Article
Language:English
Subjects:
Biopsy
Brain - pathology
Central nervous system
Cytomegalovirus
Dementia
Diagnosis
Disease
Humans
Image processing
Inclusion bodies
Intranuclear Inclusion Bodies - genetics
Intranuclear Inclusion Bodies - pathology
Literature reviews
Magnetic resonance imaging
Medicine
Medicine & Public Health
Nervous system
Neurodegenerative Diseases - diagnosis
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - pathology
Neuroimaging
Neurology
Neurons - pathology
Neuroradiology
Neurosciences
Neurosurgery
Pathogenesis
Psychiatry
Review Article
Spinal cord
Thyroid gland
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Summary:Objective To summarize the current understanding of neuronal intranuclear inclusion disease (NIID) and improve the understanding of the physician about this condition. Methods We searched PubMed with keywords related to NIID and selected publications which seemed appropriate. We analyzed its clinical features, pathogenesis, evaluation methods, treatment options, and research prospectives. Results NIID is a degenerative condition which can affect multiple organ systems especially central nervous system. Its clinical features greatly vary, and making the exact diagnosis is often difficult. There are several genes which have been associated with this disorder. Some specific signs on diffusion-weighted-imaging (DWI) sequence of magnetic resonance (MR) imaging are characteristics to NIID. Conclusion Intranuclear inclusions have been found in various nonneural cells of the body; therefore, the term systemic intranuclear inclusion disease is, perhaps, better suited to explain this disorder. There are several disorders which need to be ruled out before making the diagnosis, and neuroimaging and biopsy analysis should be combined to support the diagnosis.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-019-04195-6