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Improvements in Irritative Versus Obstructive Symptoms of the International Prostate Symptom Score After Prostatic Artery Embolization in 174 Patients, in a Single Center
Aim The aim of this study is to compare the improvements in irritative versus obstructive symptoms of the International Prostate Symptom Score (IPSS) after prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH). Materials and Methods Between 2010 and 2018, 186 patien...
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| Published in: | Cardiovascular and interventional radiology 2020-04, Vol.43 (4), p.613-619 |
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| container_title | Cardiovascular and interventional radiology |
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| creator | Moreira, Airton Mota de Assis, André Moreira Carnevale, Francisco Cesar Oliveira, Daniel Simões Antunes, Alberto Azoubel |
| description | Aim
The aim of this study is to compare the improvements in irritative versus obstructive symptoms of the International Prostate Symptom Score (IPSS) after prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH).
Materials and Methods
Between 2010 and 2018, 186 patients underwent PAE in a single center and 174 patients were retrospectively selected. The inclusion criteria were symptoms due to BPH, refractory to pharmacological treatment and IPSS ≥ 8. The mean age of the patients was 63.7 ± 7.2 years, the mean prostate volume 89.5 ± 42.5 cm
3
, and the mean IPSS 19.0 ± 6.2 points. Patient data were reviewed at baseline, 3, 12 and 24 months and compared using the ANOVA mixed models and the Tukey’s multiple comparison test.
Results
Obstructive subscores dropped more significantly than irritative subscores (
p
|
| doi_str_mv | 10.1007/s00270-019-02398-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2333607748</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2372624030</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-24edd1f2bfcf89a8631300992412f5a7f24646d5ccb37df3ce1a20305dc1ceed3</originalsourceid><addsrcrecordid>eNp9kcFq3DAQhkVpaLZpX6CHIuglh7gdSbZlH5clTRcCCWxbehOyPEodbGsryYHtI-UpI-8mKfSQkxjN9_8zzE_IBwafGYD8EgC4hAxYnQEXdZXBK7JgueAZVOWv12QBTOYZKwp2TN6GcAvAiooXb8ixYFUtSw4Lcr8ett7d4YBjDLQb6dr7LurY3SH9iT5MgV41IfrJ7L82u2Eb3RCoszT-RroeI_ox4W7UPb32LiTtM0Y3xnmkS5ugp2Zn6NKnekfPh8b13d-9eJ6clqXXqZo3OZs_NN10402PdIXzmHfkyOo-4PvH94T8-Hr-ffUtu7y6WK-Wl5kRsogZz7FtmeWNNbaqdVUKJgDqmueM20JLy_MyL9vCmEbI1gqDTHMQULSGGcRWnJDTg286zJ8JQ1RDFwz2vR7RTUFxIUQJUuZVQj_9h966Kd2jnynJS54n40TxA2XSCYJHq7a-G7TfKQZqTlIdklQpSbVPUs2ij4_WUzNg-yx5ii4B4gCE1Bpv0P-b_YLtA-TTrAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2372624030</pqid></control><display><type>article</type><title>Improvements in Irritative Versus Obstructive Symptoms of the International Prostate Symptom Score After Prostatic Artery Embolization in 174 Patients, in a Single Center</title><source>Springer Nature</source><creator>Moreira, Airton Mota ; de Assis, André Moreira ; Carnevale, Francisco Cesar ; Oliveira, Daniel Simões ; Antunes, Alberto Azoubel</creator><creatorcontrib>Moreira, Airton Mota ; de Assis, André Moreira ; Carnevale, Francisco Cesar ; Oliveira, Daniel Simões ; Antunes, Alberto Azoubel</creatorcontrib><description>Aim
The aim of this study is to compare the improvements in irritative versus obstructive symptoms of the International Prostate Symptom Score (IPSS) after prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH).
Materials and Methods
Between 2010 and 2018, 186 patients underwent PAE in a single center and 174 patients were retrospectively selected. The inclusion criteria were symptoms due to BPH, refractory to pharmacological treatment and IPSS ≥ 8. The mean age of the patients was 63.7 ± 7.2 years, the mean prostate volume 89.5 ± 42.5 cm
3
, and the mean IPSS 19.0 ± 6.2 points. Patient data were reviewed at baseline, 3, 12 and 24 months and compared using the ANOVA mixed models and the Tukey’s multiple comparison test.
Results
Obstructive subscores dropped more significantly than irritative subscores (
p
< 0.0001). The mean decrease in each IPSS item was frequency 2.4 (83%); urgency 0.8 (87%); nocturia 1.3 (49%); incomplete emptying 2.6 (83%); intermittency 2.3 (91%); weak stream 2.9 (82%); straining 1.6 (91%). The area under the curve for baseline obstructive scores was 0.7 (
p
= 0.006) and 0.59 (
p
= 0.182) for irritative scores. The most common BPH clinical manifestations include irritative and/or obstructive symptoms, the latter usually more prevalent. The IPSS drop observed after PAE suggests that it acts predominantly over obstructive symptoms (
p
< 0.0001).
Conclusion
Although a predominant improvement in obstructive symptoms may be observed after PAE, nocturia complaints may require special attention. The severity of baseline obstructive symptoms may significantly predict clinical outcomes.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-019-02398-0</identifier><identifier>PMID: 31897620</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cardiology ; Clinical Investigation ; Drug therapy ; Embolisation (arterial) ; Embolization ; Hyperplasia ; Imaging ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Patients ; Prostate ; Radiology ; Ultrasound ; Variance analysis</subject><ispartof>Cardiovascular and interventional radiology, 2020-04, Vol.43 (4), p.613-619</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2020</rights><rights>CardioVascular and Interventional Radiology is a copyright of Springer, (2020). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-24edd1f2bfcf89a8631300992412f5a7f24646d5ccb37df3ce1a20305dc1ceed3</citedby><cites>FETCH-LOGICAL-c375t-24edd1f2bfcf89a8631300992412f5a7f24646d5ccb37df3ce1a20305dc1ceed3</cites><orcidid>0000-0002-0649-2208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31897620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreira, Airton Mota</creatorcontrib><creatorcontrib>de Assis, André Moreira</creatorcontrib><creatorcontrib>Carnevale, Francisco Cesar</creatorcontrib><creatorcontrib>Oliveira, Daniel Simões</creatorcontrib><creatorcontrib>Antunes, Alberto Azoubel</creatorcontrib><title>Improvements in Irritative Versus Obstructive Symptoms of the International Prostate Symptom Score After Prostatic Artery Embolization in 174 Patients, in a Single Center</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Aim
The aim of this study is to compare the improvements in irritative versus obstructive symptoms of the International Prostate Symptom Score (IPSS) after prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH).
Materials and Methods
Between 2010 and 2018, 186 patients underwent PAE in a single center and 174 patients were retrospectively selected. The inclusion criteria were symptoms due to BPH, refractory to pharmacological treatment and IPSS ≥ 8. The mean age of the patients was 63.7 ± 7.2 years, the mean prostate volume 89.5 ± 42.5 cm
3
, and the mean IPSS 19.0 ± 6.2 points. Patient data were reviewed at baseline, 3, 12 and 24 months and compared using the ANOVA mixed models and the Tukey’s multiple comparison test.
Results
Obstructive subscores dropped more significantly than irritative subscores (
p
< 0.0001). The mean decrease in each IPSS item was frequency 2.4 (83%); urgency 0.8 (87%); nocturia 1.3 (49%); incomplete emptying 2.6 (83%); intermittency 2.3 (91%); weak stream 2.9 (82%); straining 1.6 (91%). The area under the curve for baseline obstructive scores was 0.7 (
p
= 0.006) and 0.59 (
p
= 0.182) for irritative scores. The most common BPH clinical manifestations include irritative and/or obstructive symptoms, the latter usually more prevalent. The IPSS drop observed after PAE suggests that it acts predominantly over obstructive symptoms (
p
< 0.0001).
Conclusion
Although a predominant improvement in obstructive symptoms may be observed after PAE, nocturia complaints may require special attention. The severity of baseline obstructive symptoms may significantly predict clinical outcomes.</description><subject>Cardiology</subject><subject>Clinical Investigation</subject><subject>Drug therapy</subject><subject>Embolisation (arterial)</subject><subject>Embolization</subject><subject>Hyperplasia</subject><subject>Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>Prostate</subject><subject>Radiology</subject><subject>Ultrasound</subject><subject>Variance analysis</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kcFq3DAQhkVpaLZpX6CHIuglh7gdSbZlH5clTRcCCWxbehOyPEodbGsryYHtI-UpI-8mKfSQkxjN9_8zzE_IBwafGYD8EgC4hAxYnQEXdZXBK7JgueAZVOWv12QBTOYZKwp2TN6GcAvAiooXb8ixYFUtSw4Lcr8ett7d4YBjDLQb6dr7LurY3SH9iT5MgV41IfrJ7L82u2Eb3RCoszT-RroeI_ox4W7UPb32LiTtM0Y3xnmkS5ugp2Zn6NKnekfPh8b13d-9eJ6clqXXqZo3OZs_NN10402PdIXzmHfkyOo-4PvH94T8-Hr-ffUtu7y6WK-Wl5kRsogZz7FtmeWNNbaqdVUKJgDqmueM20JLy_MyL9vCmEbI1gqDTHMQULSGGcRWnJDTg286zJ8JQ1RDFwz2vR7RTUFxIUQJUuZVQj_9h966Kd2jnynJS54n40TxA2XSCYJHq7a-G7TfKQZqTlIdklQpSbVPUs2ij4_WUzNg-yx5ii4B4gCE1Bpv0P-b_YLtA-TTrAg</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Moreira, Airton Mota</creator><creator>de Assis, André Moreira</creator><creator>Carnevale, Francisco Cesar</creator><creator>Oliveira, Daniel Simões</creator><creator>Antunes, Alberto Azoubel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0649-2208</orcidid></search><sort><creationdate>20200401</creationdate><title>Improvements in Irritative Versus Obstructive Symptoms of the International Prostate Symptom Score After Prostatic Artery Embolization in 174 Patients, in a Single Center</title><author>Moreira, Airton Mota ; de Assis, André Moreira ; Carnevale, Francisco Cesar ; Oliveira, Daniel Simões ; Antunes, Alberto Azoubel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-24edd1f2bfcf89a8631300992412f5a7f24646d5ccb37df3ce1a20305dc1ceed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cardiology</topic><topic>Clinical Investigation</topic><topic>Drug therapy</topic><topic>Embolisation (arterial)</topic><topic>Embolization</topic><topic>Hyperplasia</topic><topic>Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>Prostate</topic><topic>Radiology</topic><topic>Ultrasound</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreira, Airton Mota</creatorcontrib><creatorcontrib>de Assis, André Moreira</creatorcontrib><creatorcontrib>Carnevale, Francisco Cesar</creatorcontrib><creatorcontrib>Oliveira, Daniel Simões</creatorcontrib><creatorcontrib>Antunes, Alberto Azoubel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreira, Airton Mota</au><au>de Assis, André Moreira</au><au>Carnevale, Francisco Cesar</au><au>Oliveira, Daniel Simões</au><au>Antunes, Alberto Azoubel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvements in Irritative Versus Obstructive Symptoms of the International Prostate Symptom Score After Prostatic Artery Embolization in 174 Patients, in a Single Center</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>43</volume><issue>4</issue><spage>613</spage><epage>619</epage><pages>613-619</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Aim
The aim of this study is to compare the improvements in irritative versus obstructive symptoms of the International Prostate Symptom Score (IPSS) after prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH).
Materials and Methods
Between 2010 and 2018, 186 patients underwent PAE in a single center and 174 patients were retrospectively selected. The inclusion criteria were symptoms due to BPH, refractory to pharmacological treatment and IPSS ≥ 8. The mean age of the patients was 63.7 ± 7.2 years, the mean prostate volume 89.5 ± 42.5 cm
3
, and the mean IPSS 19.0 ± 6.2 points. Patient data were reviewed at baseline, 3, 12 and 24 months and compared using the ANOVA mixed models and the Tukey’s multiple comparison test.
Results
Obstructive subscores dropped more significantly than irritative subscores (
p
< 0.0001). The mean decrease in each IPSS item was frequency 2.4 (83%); urgency 0.8 (87%); nocturia 1.3 (49%); incomplete emptying 2.6 (83%); intermittency 2.3 (91%); weak stream 2.9 (82%); straining 1.6 (91%). The area under the curve for baseline obstructive scores was 0.7 (
p
= 0.006) and 0.59 (
p
= 0.182) for irritative scores. The most common BPH clinical manifestations include irritative and/or obstructive symptoms, the latter usually more prevalent. The IPSS drop observed after PAE suggests that it acts predominantly over obstructive symptoms (
p
< 0.0001).
Conclusion
Although a predominant improvement in obstructive symptoms may be observed after PAE, nocturia complaints may require special attention. The severity of baseline obstructive symptoms may significantly predict clinical outcomes.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31897620</pmid><doi>10.1007/s00270-019-02398-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0649-2208</orcidid></addata></record> |
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| ispartof | Cardiovascular and interventional radiology, 2020-04, Vol.43 (4), p.613-619 |
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| language | eng |
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| source | Springer Nature |
| subjects | Cardiology Clinical Investigation Drug therapy Embolisation (arterial) Embolization Hyperplasia Imaging Medicine Medicine & Public Health Nuclear Medicine Patients Prostate Radiology Ultrasound Variance analysis |
| title | Improvements in Irritative Versus Obstructive Symptoms of the International Prostate Symptom Score After Prostatic Artery Embolization in 174 Patients, in a Single Center |
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