Neurotransmitters, neuropeptides and their receptors interact with immune response in healthy and psoriatic skin

Psoriasis is a chronic inflammatory disease with a multifactorial origin that affects the skin. It is characterized by keratinocyte hyperproliferation, which results in erythemato-squamous plaques. Just as the immune system plays a fundamental role in psoriasis physiopathology, the nervous system ma...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2020-02, Vol.79, p.102004-102004, Article 102004
Main Authors: Sandoval-Talamantes, Ana Karen, Gómez-González, B.A., Uriarte-Mayorga, D.F., Martínez-Guzman, M.A., Wheber-Hidalgo, Katia Alejandra, Alvarado-Navarro, Anabell
Format: Article
Language:English
Subjects:
Adenosine
Calcitonin
Calcitonin gene-related peptide
Chemical mediators
Glucagon
Histamine
Immune cells
Immune response
Immune system
Inflammatory diseases
Intestine
Nerve growth factor
Nervous system
Neurogenic inflammation
Neuropeptides
Neurotransmitters
Peptides
Plaques
Psoriasis
Serotonin
Somatostatin
Substance P
Vasoactive agents
Vasoactive intestinal peptide
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Summary:Psoriasis is a chronic inflammatory disease with a multifactorial origin that affects the skin. It is characterized by keratinocyte hyperproliferation, which results in erythemato-squamous plaques. Just as the immune system plays a fundamental role in psoriasis physiopathology, the nervous system maintains the inflammatory process through the neuropeptides and neurotransmitters synthesis, as histamine, serotonin, calcitonin gene-related peptide, nerve growth factor, vasoactive intestinal peptide, substance P, adenosine, glucagon-like peptide, somatostatin and pituitary adenylate cyclase polypeptide. In patients with psoriasis, the systemic or in situ expression of these chemical mediators and their receptors are altered, which affects the clinical activity of patients due to its link to the immune system, provoking neurogenic inflammation. It is important to establish the role of the nervous system since it could represent a therapeutic alternative for psoriasis patients. The aim of this review is to offer a detailed review of the current literature about the neuropeptides and neurotransmitters involved in the physiopathology of psoriasis. •Immune and nervous systems cooperate via chemical mediators to maintain homeostasis.•The chemical mediators include neurotransmitters and neuropeptides.•Immune cells synthesize and respond to neurotransmitters and neuropeptides.•The imbalance of chemical mediators in skin lead to diseases, such as psoriasis.•Neurotransmitters and neuropeptides emerge as new therapeutic targets.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2019.102004