Evolutions in cardiac and gonadal ultra-structure during a “cycle” of androgenic anabolic abuse in adult male mice

• Published in: Steroids 2020-03, Vol.155, p.108571-108571, Article 108571
• Main Authors: Kahal, Aida, Allem, Rachida, Zahzeh, Touria, Koriche, Sana, Kouri, Amina, Douani, Asma, Kassoul, Hadjira, Ababou, Adda
• Format: Article
• Language: English
• Subjects: Anabolic Agents - administration & dosage; Anabolic Agents - pharmacology; Androgenic drugs; Androgens - administration & dosage; Androgens - pharmacology; Animals; Cycling; Disease Models, Animal; Doping; Gonads - drug effects; Gonads - pathology; Heart; Heart - drug effects; Male; Mice; Nandrolone Decanoate - administration & dosage; Nandrolone Decanoate - pharmacology; Substance Abuse Detection; Testis; Ultra-structure
• ISSN: 0039-128X; 1878-5867
• DOI: 10.1016/j.steroids.2019.108571

•This study tested the usefulness of AAS taking by “Cycling”.•It’s the only one morphometric studies done for this purpose.•So, the use of AAS with “Cycling” may lead to irreversibly destroy of the heart.•Either, "Cycling" doesn’t ensure the complete recovery of fertility in AAS abuser.•Therefore, physicians should take these damages in mind seriously. The importance of the present study comes from the lack of sufficient information about the reversibility of the potential histopathological alterations which may result from anabolic androgenic drugs abuse by “Cycling” protocol. So, the aim of this study is to explore the negative effects of Deca-Durabolin abuse in cardiac and gonadal ultra-structures during an administration cycle. For our purpose, study was performed on 40 male adult mices. Animals were divided into five groups of 8 animals each treated weekly by Deca-Durabolin (nandrolone decanoate) at 30 g/kg of BW during one month (GI); during two months (GII); during three months (GIII); during three months followed by six weeks of treatment discontinuation (GIV) and Control (C). Cytohistological examinations to determine the histopathological damage properties of the heart and tests were performed. Our results showed that the animals supported very well the administrated substance. Our study showed important degenerative changes in cardiac and gonadal tissues after one months of androgen abuse. These damages increases with the duration of treatment with well marked cell lesions, and worsen again 6 weeks after stopping treatment in cardiac tissue, whereas the gonadal tissue does not recover completely during this period. These results ported that the use of AAS with “Cycling” may lead to irreversibly destroy the heart tissue. Either, “Cycling” does not ensure the complete recovery of fertility in AAS abusers.