Does SEN-V and other non-A-E hepatotropic viruses contribute to the development and progression of non-alcoholic fatty liver disease?

Approximately 10–20% of patients with non-alcoholic fatty liver disease (NAFLD) are at risk of progressing to cirrhosis. The cause of such progression is unclear. SEN-V is a hepatotropic virus that has been associated with more severe and advanced liver disease in patients with chronic hepatitis C v...

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Bibliographic Details
Published in:Medical hypotheses 2020-04, Vol.137, p.109528-109528, Article 109528
Main Authors: Grubert Van Iderstine, M., Osiowy, C., Rumbolt, C., Zhang, M., Swidinsky, K., Kaita, K.D.E., Minuk, G.Y.
Format: Article
Language:English
Subjects:
Disease Progression
DNA Viruses
Hepatitis C, Chronic - complications
Humans
Liver Cirrhosis
Non-alcoholic Fatty Liver Disease
Torque teno virus
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Summary:Approximately 10–20% of patients with non-alcoholic fatty liver disease (NAFLD) are at risk of progressing to cirrhosis. The cause of such progression is unclear. SEN-V is a hepatotropic virus that has been associated with more severe and advanced liver disease in patients with chronic hepatitis C virus infections. In this study we tested 32 NAFLD patients for evidence of SEN-V infection and correlated the results with histologic findings. The results of the study revealed similar disease severity and stage of progression in SEN-V positive and negative patients. Although not supportive of our hypothesis, the possibility that SEN-V and/or other non-A-E hepatotropic viruses contribute to the development and course of NAFLD is discussed.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2019.109528