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Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives

Tissue adhesives are commonly used in surgeries and regenerative engineering for the repair and regeneration of topical and internal wounds on tissues and organs such as skin, heart, blood vessels, and bone. However, achieving rapid crosslinking, strong wet adhesion and cohesion strengths, and minim...

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Bibliographic Details
Published in:Biomaterials 2020-02, Vol.232, p.119719-119719, Article 119719
Main Authors: Lu, Xili, Shi, Sanjun, Li, Hanmei, Gerhard, Ethan, Lu, Zhihui, Tan, Xinyu, Li, Wenliang, Rahn, Kevin M., Xie, Denghui, Xu, Guodong, Zou, Fang, Bai, Xiaochun, Guo, Jinshan, Yang, Jian
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Language:English
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Summary:Tissue adhesives are commonly used in surgeries and regenerative engineering for the repair and regeneration of topical and internal wounds on tissues and organs such as skin, heart, blood vessels, and bone. However, achieving rapid crosslinking, strong wet adhesion and cohesion strengths, and minimal cytotoxicity remains a critical roadblock for clinical translation. Herein, in contrast to harsh and cytotoxic oxidants, magnesium oxide (MgO) particles were found to facilitate rapid crosslinking for injectable citrate-based mussel-inspired tissue bioadhesives synthesized by reacting citric acid, PEG-PPG-PEG diol and dopamine (iC-EPE). Our results confirmed the role of MgO particles as both crosslinkers and composite fillers to concurrently enhance bioadhesive cohesion and adhesion. iC-EPE crosslinked by MgO with/without sodium periodate (PI) exhibit enhanced mechanical strengths (1.0 Mpa 
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2019.119719