Cycloartane triterpenoids from Pseudolarix amabilis and their antiviral activity

• Published in: Phytochemistry (Oxford) 2020-03, Vol.171, p.112229-112229, Article 112229
• Main Authors: Zhao, Xiao-Tong, Yu, Mei-Hua, Su, Shi-Yun, Shi, Xun-Long, Lei, Chun, Hou, Ai-Jun
• Format: Article
• Language: English
• Subjects: Antiviral activity; Antiviral Agents - chemistry; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; Crystallography, X-Ray; Cycloartane triterpenoids; Herpesvirus 1, Human - drug effects; Influenza A Virus, H3N2 Subtype - drug effects; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Phytochemicals - chemistry; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; Pinaceae; Pinaceae - chemistry; Pseudolarix amabilis (J. Nelson) Rehder; Pseudolarnoids A−G; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2019.112229

Seven undescribed cycloartane triterpenoids, pseudolarnoids A−G, together with ten known ones, were isolated from the seeds of Pseudolarix amabilis (J. Nelson) Rehder. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography, and ECD data. Pseudolarnoids A−C are cycloartane triterpenoids with a unique 16S, 23R-spirolactone moiety. Pseudolarnoids F, G, and pseudolarolide C demonstrated potent antiviral effects on HSV-1 in vitro. Seven undescribed cycloartane triterpenoids, pseudolarnoids A−G, together with ten known ones, were isolated from Pseudolarix amabilis. Pseudolarnoids A−C are cycloartane triterpenoids with a unique 16S, 23R-spirolactone moiety. Some isolates demonstrated potent antiviral effects on HSV-1 in vitro. [Display omitted] •Seven undescribed cycloartane triterpenoids were isolated from Pseudolarix amabilis.•Cycloartane triterpenoids with a unique 16S, 23R-spirolactone motif are reported.•Some of the triterpenoids showed significant antiviral effects on HSV-1.