Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene

Replacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mos...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2019-05, Vol.17 (5), p.387-393
Main Authors: ZHOU, Zhen-Zhen, ZHU, Hong-Jie, YANG, Cheng-Long, LIU, Yan-Jun, JIANG, Nan, XIAO, Yong-Sheng, SHI, Li-Yun, JIAO, Rui-Hua, GE, Hui-Ming, TAN, Ren-Xiang
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - metabolism
Anti-Inflammatory Agents - pharmacology
Cyclopentanes - chemistry
Cyclopentanes - isolation & purification
Cyclopentanes - metabolism
Cyclopentanes - pharmacology
Cyclopentenone
Daldinia eschscholzii
Fungal Proteins - genetics
Fungal Proteins - metabolism
Global regulator
Interleukin-6 - metabolism
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Macrophages - metabolism
Mice
Molecular Structure
Promoter Regions, Genetic - genetics
RAW 264.7 Cells
Transcription Factors - genetics
Transcription Factors - metabolism
Tumor Necrosis Factor-alpha - metabolism
Xylariales - chemistry
Xylariales - genetics
Xylariales - metabolism
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Summary:Replacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher’s reaction, and electronic circular dichroism (ECD). Dalestones A and B inhibit the gene expression of TNF-α and IL-6 in LPS-induced RAW264.7 macrophages.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(19)30045-7