Defining a cohort of oligometastatic nasopharyngeal carcinoma patients with improved clinical outcomes

Objectives To compare the clinical outcomes of oligometastatic versus widely metastatic NPC patients. Materials and Methods Retrospective review of 157 patients with metastatic NPC at a tertiary hospital was performed. Multivariate analysis was carried out to compare the overall and progression‐free...

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Bibliographic Details
Published in:Head & neck 2020-05, Vol.42 (5), p.945-954
Main Authors: Chee, Jeremy, Liu, Xuandao, Eu, Donovan, Loh, Thomas, Ho, Francis, Wong, Lea C., Tham, Ivan, Tan, Chee S., Goh, Boon C., Lim, Chwee M.
Format: Article
Language:English
Subjects:
Clinical outcomes
distant metastasis
Head and neck
Lesions
Metastases
Metastasis
Multivariate analysis
Nasopharyngeal carcinoma
oligometastasis
Patients
Survival
Throat cancer
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Summary:Objectives To compare the clinical outcomes of oligometastatic versus widely metastatic NPC patients. Materials and Methods Retrospective review of 157 patients with metastatic NPC at a tertiary hospital was performed. Multivariate analysis was carried out to compare the overall and progression‐free survival (OS and PFS) of these two cohorts of NPC patients. The number of organ involvement and discrete metastatic lesions associated with improved OS and PFS were ascertained. Results Patients with oligometastatic NPC (single organ, less than six discrete metastatic lesions) had a better median OS than patients with widespread metastasis (24.8 versus 12.8 months, P 
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26061