The potential function of endometrial‐secreted factors for endometrium remodeling during the estrous cycle

Uterine has a pivotal role in implantation and conceptus development. To prepare a conducive uterine condition for possibly new gestation during the estrous cycle, uterine endometrium undergoes dramatic remodeling. In addition, angiogenesis is an indispensable biological process of endometrium remod...

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Bibliographic Details
Published in:Animal science journal 2020-01, Vol.91 (1), p.e13333-n/a
Main Authors: Billhaq, Dody Houston, Lee, Sang‐Hee, Lee, Seunghyung
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inducing Agents
Animals
Biological activity
Blood vessels
Carrier Proteins - metabolism
Cell Adhesion
Cell adhesion & migration
Cell migration
Cell Movement
Cell Proliferation
Collagen (type IV)
Collagen Type IV - metabolism
endometrial remodeling
Endometrium
Endometrium - blood supply
Endometrium - cytology
Endometrium - metabolism
Endometrium - physiology
estrous cycle
Estrous Cycle - physiology
Estrus cycle
Female
Gestation
Growth factors
LIM Domain Proteins - metabolism
Myoglobin - metabolism
Myoglobins
Proteins
Secretions
Substrates
Uterus
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
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Summary:Uterine has a pivotal role in implantation and conceptus development. To prepare a conducive uterine condition for possibly new gestation during the estrous cycle, uterine endometrium undergoes dramatic remodeling. In addition, angiogenesis is an indispensable biological process of endometrium remodeling. Furthermore, essential protein expressions related to important biological processes of endometrium remodeling, which are vascular endothelial growth factor (VEGF), myoglobin (MYG), collagen type IV (COL4), fucosyltransferase IV (FUT4), and cysteine‐rich protein 2 (CRP2), were detected in the endometrial tissue reported in many previous studies and recently discovered in histotroph substrates during the estrous cycle. Those proteins, which are liable for provoking new vessel development, cell proliferation, cell adhesion, and cell migration, were expressed higher in the histotroph during the luteal phase than follicular phase. Histotroph proteins considerably contribute to endometrium remodeling during the estrous cycle. To that end, the following review will discuss and highlight the relevant information and evidence of the uterine fluid proteins as endometrial‐secreted factors that adequately indicate the potential role of the uterine secretions to be involved in the endometrial remodeling process.
ISSN:1344-3941
1740-0929
DOI:10.1111/asj.13333