Extreme neonatal hyperbilirubinemia and kernicterus spectrum disorder in Denmark during the years 2000–2015

Objective To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015. Study design We identified all infants born between 01.01.2000 and 31.12.2015 with T...

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Bibliographic Details
Published in:Journal of perinatology 2020-02, Vol.40 (2), p.194-202
Main Authors: Donneborg, Mette Line, Hansen, Bo Moelholm, Vandborg, Pernille Kure, Rodrigo-Domingo, María, Ebbesen, Finn
Format: Article
Language:English
Subjects:
692/308/409
692/699/375/1345
ABO system
Age
Babies
Bilirubin
Bilirubin - blood
Blood groups
Cerebral palsy
Cohort Studies
Demography
Denmark - epidemiology
Development and progression
Etiology
Exchange Transfusion, Whole Blood
Female
Gestational Age
Glucosephosphate Dehydrogenase Deficiency - epidemiology
Health visiting
Hearing loss
Hospitals
Humans
Hyperbilirubinemia
Hyperbilirubinemia, Neonatal - complications
Hyperbilirubinemia, Neonatal - epidemiology
Hyperbilirubinemia, Neonatal - therapy
Incidence
Infant, Newborn
Infants
Infants (Newborn)
Jaundice
Jaundice, Neonatal
Kernicterus
Kernicterus - diagnosis
Kernicterus - epidemiology
Kernicterus - etiology
Laboratories
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Neonatal jaundice
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Phototherapy
Surveillance
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Summary:Objective To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015. Study design We identified all infants born between 01.01.2000 and 31.12.2015 with TSB ≥450 µmol/L, ratio of conjugated to TSB
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-019-0566-8