Prenylated p‑Terphenyls from a Mangrove Endophytic Fungus, Aspergillus candidus LDJ‑5

Nine previously undescribed prenylated p-terphenyls, prenylterphenyllins F–J (1, 2, 4–6) and prenylcandidusins D–G (3, 7–9), were isolated from an endophytic fungus, Aspergillus candidus LDJ-5. Their structures were determined from NMR and MS data. Differing from previously reported p-terphenyls, co...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2020-01, Vol.83 (1), p.8-13
Main Authors: Zhou, Guoliang, Chen, Xiaohui, Zhang, Xiaomin, Che, Qian, Zhang, Guojian, Zhu, Tianjiao, Gu, Qianqun, Li, Dehai
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Aspergillus - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Terphenyl Compounds - chemistry
Terphenyl Compounds - pharmacology
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Summary:Nine previously undescribed prenylated p-terphenyls, prenylterphenyllins F–J (1, 2, 4–6) and prenylcandidusins D–G (3, 7–9), were isolated from an endophytic fungus, Aspergillus candidus LDJ-5. Their structures were determined from NMR and MS data. Differing from previously reported p-terphenyls, compound 3 represents a rare 6,5,6,6-fused ring system. Compounds 4–6 are antimicrobial, and compounds 1, 4, 6, and 9 are cytotoxic.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.9b00004