Metacognitive impairment in patients with episodic and chronic migraine

• Published in: Journal of clinical neuroscience 2020-02, Vol.72, p.119-123
• Main Authors: Zucca, Milena, Rubino, Elisa, Vacca, Alessandro, De Martino, Paola, Roveta, Fausto, Govone, Flora, Gai, Annalisa, Caglio, Marcella, Gentile, Salvatore, Giordana, Maria T., Rainero, Innocenzo
• Format: Article
• Language: English
• Subjects: Executive functions; Medication-overuse headache; Metacognition; Migraine; Wisconsin card sorting test
• ISSN: 0967-5868; 1532-2653
• DOI: 10.1016/j.jocn.2019.12.048

•Migraine patients show metacognitive control dysfunctions.•Metacognitive problems appear to get worse with the presence of medication overuse.•Metacognitive deficits may become a new therapeutic target in migraine patients. Migraine is one of the most common medical disorder in the world. Metacognition is the ability to monitor one’s own cognitive functioning and consequently direct one’s behavior. In adult migraine patients, the neuropsychological profile has been poorly investigated, and metacognitive functions have never been assessed. The aim of the present study was therefore to evaluate executive metacognitive abilities in patients with episodic and chronic migraine. Sixty-four migraine patients (male/female = 18/46; mean age = 45.65 ± 11.61 years): 27 patients with episodic migraine without aura (male/female = 9/18; mean age ± SD = 45.11 ± 12.18 years) and 37 patients with chronic migraine and medication-overuse headache (male/female = 9/28; mean age ± SD = 46.05 ± 11.32 years) were selected for the study. Twenty-nine controls (male/female = 12/17; mean age ± SD = 42.86 ± 14.78 years) were also enrolled in the research. Metacognitive and executive skills were assessed using the metacognitive version of Wisconsin Card Sorting Test. Migraine patients exhibited a lower performance in metacognitive tasks in respect to controls in term of worse outcomes in accuracy score (p = 0.012), global monitoring (p = 0.015), monetary gains (p = 0.022), and control sensitivity (p = 0.027). A reduction in accuracy score (p = 0.001), free-choice improvement (p = 0.002), global monitoring (p = 0.003), monetary gains (p = 0.009), and control sensitivity (p