Model self-assembling arginine-based tripeptides show selective activity against Pseudomonas bacteria

Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nu...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (4), p.615-618
Main Authors: Castelletto, Valeria, Edwards-Gayle, Charlotte J C, Hamley, Ian W, Barrett, Glyn, Seitsonen, Jani, Ruokolainen, Janne, de Mello, Lucas Rodrigues, da Silva, Emerson Rodrigo
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Arginine - chemistry
Arginine - pharmacology
Binding
Biofilms - drug effects
Cell Line
Cell Survival - drug effects
Fibroblasts - drug effects
Humans
Models, Molecular
Nucleotides
Oligopeptides - chemical synthesis
Oligopeptides - chemistry
Oligopeptides - pharmacology
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
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Summary:Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc07257h