Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

Inflammasomes are innate immune mechanisms that promote inflammation by activating the protease caspase‐1. Active caspase‐1 induces pyroptosis, a necrotic form of regulated cell death, which facilitates the release of intracellular proinflammatory molecules, including IL‐1 family cytokines. Recent s...

Full description

Saved in:
Bibliographic Details
Published in:Microbiology and immunology 2020-04, Vol.64 (4), p.252-269
Main Author: Tsuchiya, Kohsuke
Format: Article
Language:English
Subjects:
Apoptosis
Caspase
caspase‐1
Cell death
gasdermin D
inflammasome
Inflammasomes
Inflammatory diseases
Molecular modelling
Physiology
Pyroptosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inflammasomes are innate immune mechanisms that promote inflammation by activating the protease caspase‐1. Active caspase‐1 induces pyroptosis, a necrotic form of regulated cell death, which facilitates the release of intracellular proinflammatory molecules, including IL‐1 family cytokines. Recent studies identified mediators of inflammasome‐associated cell death and suggested that inflammasomes induce not only pyroptosis, but also apoptosis. Caspase‐1 has the potential to induce pyroptosis and apoptosis in a manner that is dependent on the expression of the pyroptosis mediator gasdermin D. Caspase‐1‐induced apoptosis is mediated by Bid and caspase‐7. Caspase‐8 is also activated following the formation of inflammasomes and may induce apoptosis. Because inflammasomes contribute to the pathogenesis of inflammatory disorders and host defenses against microbial pathogens, a more detailed understanding of the mechanisms underlying inflammasome‐associated cell death may contribute to the development of novel therapeutic strategies for inflammasome‐related diseases. Pyroptosis has been implicated in inflammasome‐related diseases, and compounds that inhibit this process have been reported. The molecular mechanisms of inflammasome‐associated cell death and its physiological implications are discussed herein.
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.12771