Cytotoxic Activity of Cunila angustifolia Essential Oil

The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC‐FID and GC‐MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and other compounds such as menthone (8.6 %), n...

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Bibliographic Details
Published in:Chemistry & biodiversity 2020-02, Vol.17 (2), p.e1900656-n/a
Main Authors: Sousa, Matheus H. O., Morgan, Jessica M. S., Cesca, Karina, Flach, Adriana, Moura, Neusa F.
Format: Article
Language:English
Subjects:
Acetic acid
Biotechnology
Breast
Caryophyllene
Caryophyllene oxide
Cell Line, Tumor
Cell Survival - drug effects
Chemical composition
Cunila
Cunila angustifolia
Cytotoxicity
essential oil
Essential oils
Gas Chromatography-Mass Spectrometry
Humans
Lamiaceae - chemistry
Lamiaceae - metabolism
Melanoma
menthol
Menthone
Oils & fats
Oils, Volatile - analysis
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Organic chemistry
Plant Leaves - chemistry
Plant Leaves - metabolism
Pulegone
Selectivity
terpene
Tumor cell lines
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Summary:The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC‐FID and GC‐MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and other compounds such as menthone (8.6 %), neomenthol (7.2 %), menthyl acetate (2.5 %) and caryophyllene oxide (2.0 %) were identified. The cytotoxic activity of the essential oil was evaluated by MTS assay, with the human cancer cell lines of the lung (A549), breast (MCF‐7) and skin melanoma (SK‐Mel‐28). The assay showed the highest selectivity, to MCF‐7 cell lines, with IC50 equal to 34.0 μg mL−1, low selectivity for SK‐Mel‐28 cell lines, with IC50 equal to 279.9 μg mL−1, and no mortality to A549 cell lines.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201900656