Interrupting Sitting Time with Simple Resistance Activities Lowers Postprandial Insulinemia in Adults with Overweight or Obesity

Objective This study aimed to examine the effects on postprandial glucose and insulin responses of interrupting sitting time with brief bouts of simple resistance activities (SRAs) in adults with overweight or obesity. Methods Participants (n = 19) were recruited for a randomized crossover trial inv...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2019-09, Vol.27 (9), p.1428-1433
Main Authors: Larsen, Robyn, Ali, Hamza, Dempsey, Paddy C., Grace, Megan, Dillon, Francis, Kingwell, Bronwyn A., Cohen, Neale, Owen, Neville, Green, Daniel J., Dunstan, David W.
Format: Article
Language:English
Subjects:
Adult
Aged
Cardiovascular disease
Cross-Over Studies
Exercise - physiology
Female
Glucose
Humans
Insulin - metabolism
Insulin resistance
Male
Middle Aged
Obesity
Obesity - therapy
Overweight - therapy
Postprandial Period - physiology
Sitting Position
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Summary:Objective This study aimed to examine the effects on postprandial glucose and insulin responses of interrupting sitting time with brief bouts of simple resistance activities (SRAs) in adults with overweight or obesity. Methods Participants (n = 19) were recruited for a randomized crossover trial involving the following two 6‐hour conditions: (1) uninterrupted sitting or (2) sitting with 3‐minute bouts of SRAs (half‐squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (total duration = 27 minutes). Incremental areas under the curve (iAUC) for glucose, insulin, and insulin:glucose ratio were analyzed as prespecified secondary outcomes using mixed‐effects log‐linear regression adjusted for sex, BMI, treatment order, and preprandial values. Results are reported as multiplicative change (exponentiated coefficient [EC] with 95% CI) relative to the control condition. Results Glucose iAUC during the SRA condition was not significantly different from the prolonged sitting condition (EC = 0.92; 95% CI: 0.73‐1.16; P = 0.43). However, SRAs lowered the postprandial insulin response by 26% (EC = 0.74; 95% CI: 0.64‐0.85; P 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.22554