Loading…

The CU PAO: A Minimally Invasive, 2-Incision, Interlocking Periacetabular Osteotomy: Technique and Early Results

The aims of this study were to describe a novel minimally invasive, interlocking periacetabular osteotomy (PAO) for the treatment of hip dysplasia that was developed at our institution and to report on its safety, complications, and early clinical outcomes. This was a prospective longitudinal study...

Full description

Saved in:
Bibliographic Details
Published in:Journal of bone and joint surgery. American volume 2019-08, Vol.101 (16), p.1495-1504
Main Authors: Mei-Dan, Omer, Welton, K. Linnea, Kraeutler, Matthew J., Young, David A., Raju, Sivashanmugam, Garabekyan, Tigran
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c2099-1536953dee8487385ce2f9e0da8d80f93d3fda84a23d198c5bc93fe7f5e4fd333
container_end_page 1504
container_issue 16
container_start_page 1495
container_title Journal of bone and joint surgery. American volume
container_volume 101
creator Mei-Dan, Omer
Welton, K. Linnea
Kraeutler, Matthew J.
Young, David A.
Raju, Sivashanmugam
Garabekyan, Tigran
description The aims of this study were to describe a novel minimally invasive, interlocking periacetabular osteotomy (PAO) for the treatment of hip dysplasia that was developed at our institution and to report on its safety, complications, and early clinical outcomes. This was a prospective longitudinal study of the first 200 consecutive hips that underwent the CU (University of Colorado) PAO, an interlocking osteotomy combining the benefits of the Birmingham interlocking pelvic osteotomy (BIPO) and the Ganz PAO. The technique provides direct visualization of the sciatic nerve during the ischial osteotomy and allows for immediate weight-bearing postoperatively. Demographic characteristics, intraoperative and perioperative parameters, and functional outcomes were documented. All patients underwent hip arthroscopy 3 to 10 days prior to the PAO to address concomitant intra-articular pathology. Mechanical deep venous thrombosis (DVT) prophylaxis was used for 2 weeks postoperatively. Results were stratified to compare the first 100 and the second 100 cases. A total of 161 patients (200 hips) underwent primary PAO; mean follow-up was 20 months (range, 3 to 33 months). The mean patient age at the time of surgery was 29.4 years (range, 13 to 55 years). Females accounted for 89% of the patients included in this study. The average length of stay was 4 days. A concomitant proximal femoral derotational osteotomy was performed in 19 hips. The lateral center-edge angle (LCEA) improved from a mean of 18.8° preoperatively to 31.5° postoperatively (p < 0.001). The mean Non-Arthritic Hip Score (NAHS) improved from 56.0 preoperatively to 89.4 at the 24-month follow-up (p < 0.0001). Paresthesias in the distribution of the lateral femoral cutaneous nerve were common (65% at 2 weeks postoperatively) but resolved in 85% of the patients within the first 6 months. There were no sciatic nerve-related complications, deep infections, or DVTs. The CU PAO enables corrective realignment of symptomatic acetabular dysplasia with direct visualization of the sciatic nerve, early weight-bearing, cosmetic incisions, and good short-term outcomes. Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
doi_str_mv 10.2106/JBJS.19.00005
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2335175929</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2335175929</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2099-1536953dee8487385ce2f9e0da8d80f93d3fda84a23d198c5bc93fe7f5e4fd333</originalsourceid><addsrcrecordid>eNo9kEFvEzEQRi0EoqFw5Ip85FAH27Pe2L2FqECqolSQni3HO0tMnd1g77bKv8dpCnPx6NPTZ_sR8l7wqRS8_nT9-frnVJgpL6NekIlQoJgAXb8kE86lYAaUOiNvcv5diKris9fkDEQFda30hOzXW6SLO3o7X13SOf0eurBzMR7osntwOTzgBZVs2fmQQ99dlHTAFHt_H7pf9BZTcB4HtxmjS3SVB-yHfne4pGv02y78GZG6rqFXLpXCH5jHOOS35FXrYsZ3z-c5uftytV58Yzerr8vF_IZ5yY1h5Ru1UdAg6krPQCuPsjXIG6cbzVsDDbRlr5yERhjt1cYbaHHWKqzaBgDOycdT7z715SF5sLuQPcboOuzHbCWAEjNlpCkoO6E-9TknbO0-FQvpYAW3R8n2KNkKY58kF_7Dc_W42WHzn_5ntQDVCXjsY_GV7-P4iMlu0cVh-1RS1RKY5MJwXS5gx8jAX1mchow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2335175929</pqid></control><display><type>article</type><title>The CU PAO: A Minimally Invasive, 2-Incision, Interlocking Periacetabular Osteotomy: Technique and Early Results</title><source>HEAL-Link subscriptions: Lippincott Williams &amp; Wilkins</source><creator>Mei-Dan, Omer ; Welton, K. Linnea ; Kraeutler, Matthew J. ; Young, David A. ; Raju, Sivashanmugam ; Garabekyan, Tigran</creator><creatorcontrib>Mei-Dan, Omer ; Welton, K. Linnea ; Kraeutler, Matthew J. ; Young, David A. ; Raju, Sivashanmugam ; Garabekyan, Tigran</creatorcontrib><description>The aims of this study were to describe a novel minimally invasive, interlocking periacetabular osteotomy (PAO) for the treatment of hip dysplasia that was developed at our institution and to report on its safety, complications, and early clinical outcomes. This was a prospective longitudinal study of the first 200 consecutive hips that underwent the CU (University of Colorado) PAO, an interlocking osteotomy combining the benefits of the Birmingham interlocking pelvic osteotomy (BIPO) and the Ganz PAO. The technique provides direct visualization of the sciatic nerve during the ischial osteotomy and allows for immediate weight-bearing postoperatively. Demographic characteristics, intraoperative and perioperative parameters, and functional outcomes were documented. All patients underwent hip arthroscopy 3 to 10 days prior to the PAO to address concomitant intra-articular pathology. Mechanical deep venous thrombosis (DVT) prophylaxis was used for 2 weeks postoperatively. Results were stratified to compare the first 100 and the second 100 cases. A total of 161 patients (200 hips) underwent primary PAO; mean follow-up was 20 months (range, 3 to 33 months). The mean patient age at the time of surgery was 29.4 years (range, 13 to 55 years). Females accounted for 89% of the patients included in this study. The average length of stay was 4 days. A concomitant proximal femoral derotational osteotomy was performed in 19 hips. The lateral center-edge angle (LCEA) improved from a mean of 18.8° preoperatively to 31.5° postoperatively (p &lt; 0.001). The mean Non-Arthritic Hip Score (NAHS) improved from 56.0 preoperatively to 89.4 at the 24-month follow-up (p &lt; 0.0001). Paresthesias in the distribution of the lateral femoral cutaneous nerve were common (65% at 2 weeks postoperatively) but resolved in 85% of the patients within the first 6 months. There were no sciatic nerve-related complications, deep infections, or DVTs. The CU PAO enables corrective realignment of symptomatic acetabular dysplasia with direct visualization of the sciatic nerve, early weight-bearing, cosmetic incisions, and good short-term outcomes. Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.</description><identifier>ISSN: 0021-9355</identifier><identifier>EISSN: 1535-1386</identifier><identifier>DOI: 10.2106/JBJS.19.00005</identifier><identifier>PMID: 31436658</identifier><language>eng</language><publisher>United States: The Journal of Bone and Joint Surgery, Inc</publisher><subject>Acetabulum - diagnostic imaging ; Acetabulum - surgery ; Adolescent ; Adult ; Age Factors ; Colorado ; Female ; Hip Dislocation - diagnostic imaging ; Hip Dislocation - surgery ; Hospitals, University ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures - methods ; Osteotomy - adverse effects ; Osteotomy - methods ; Pain Measurement ; Patient Safety - statistics &amp; numerical data ; Postoperative Care - methods ; Preoperative Care - methods ; Prospective Studies ; Radiography - methods ; Range of Motion, Articular - physiology ; Recovery of Function ; Severity of Illness Index ; Sex Factors ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of bone and joint surgery. American volume, 2019-08, Vol.101 (16), p.1495-1504</ispartof><rights>The Journal of Bone and Joint Surgery, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2099-1536953dee8487385ce2f9e0da8d80f93d3fda84a23d198c5bc93fe7f5e4fd333</cites><orcidid>0000-0002-8363-5647 ; 0000-0002-0331-107 ; 0000-0002-2276-7814 ; 0000-0001-7555-986 ; 0000-0001-9947-6655 ; 0000-0002-5021-9620 ; 0000-0002-0331-107X ; 0000-0001-7555-986X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31436658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mei-Dan, Omer</creatorcontrib><creatorcontrib>Welton, K. Linnea</creatorcontrib><creatorcontrib>Kraeutler, Matthew J.</creatorcontrib><creatorcontrib>Young, David A.</creatorcontrib><creatorcontrib>Raju, Sivashanmugam</creatorcontrib><creatorcontrib>Garabekyan, Tigran</creatorcontrib><title>The CU PAO: A Minimally Invasive, 2-Incision, Interlocking Periacetabular Osteotomy: Technique and Early Results</title><title>Journal of bone and joint surgery. American volume</title><addtitle>J Bone Joint Surg Am</addtitle><description>The aims of this study were to describe a novel minimally invasive, interlocking periacetabular osteotomy (PAO) for the treatment of hip dysplasia that was developed at our institution and to report on its safety, complications, and early clinical outcomes. This was a prospective longitudinal study of the first 200 consecutive hips that underwent the CU (University of Colorado) PAO, an interlocking osteotomy combining the benefits of the Birmingham interlocking pelvic osteotomy (BIPO) and the Ganz PAO. The technique provides direct visualization of the sciatic nerve during the ischial osteotomy and allows for immediate weight-bearing postoperatively. Demographic characteristics, intraoperative and perioperative parameters, and functional outcomes were documented. All patients underwent hip arthroscopy 3 to 10 days prior to the PAO to address concomitant intra-articular pathology. Mechanical deep venous thrombosis (DVT) prophylaxis was used for 2 weeks postoperatively. Results were stratified to compare the first 100 and the second 100 cases. A total of 161 patients (200 hips) underwent primary PAO; mean follow-up was 20 months (range, 3 to 33 months). The mean patient age at the time of surgery was 29.4 years (range, 13 to 55 years). Females accounted for 89% of the patients included in this study. The average length of stay was 4 days. A concomitant proximal femoral derotational osteotomy was performed in 19 hips. The lateral center-edge angle (LCEA) improved from a mean of 18.8° preoperatively to 31.5° postoperatively (p &lt; 0.001). The mean Non-Arthritic Hip Score (NAHS) improved from 56.0 preoperatively to 89.4 at the 24-month follow-up (p &lt; 0.0001). Paresthesias in the distribution of the lateral femoral cutaneous nerve were common (65% at 2 weeks postoperatively) but resolved in 85% of the patients within the first 6 months. There were no sciatic nerve-related complications, deep infections, or DVTs. The CU PAO enables corrective realignment of symptomatic acetabular dysplasia with direct visualization of the sciatic nerve, early weight-bearing, cosmetic incisions, and good short-term outcomes. Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.</description><subject>Acetabulum - diagnostic imaging</subject><subject>Acetabulum - surgery</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Colorado</subject><subject>Female</subject><subject>Hip Dislocation - diagnostic imaging</subject><subject>Hip Dislocation - surgery</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minimally Invasive Surgical Procedures - methods</subject><subject>Osteotomy - adverse effects</subject><subject>Osteotomy - methods</subject><subject>Pain Measurement</subject><subject>Patient Safety - statistics &amp; numerical data</subject><subject>Postoperative Care - methods</subject><subject>Preoperative Care - methods</subject><subject>Prospective Studies</subject><subject>Radiography - methods</subject><subject>Range of Motion, Articular - physiology</subject><subject>Recovery of Function</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0021-9355</issn><issn>1535-1386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNo9kEFvEzEQRi0EoqFw5Ip85FAH27Pe2L2FqECqolSQni3HO0tMnd1g77bKv8dpCnPx6NPTZ_sR8l7wqRS8_nT9-frnVJgpL6NekIlQoJgAXb8kE86lYAaUOiNvcv5diKris9fkDEQFda30hOzXW6SLO3o7X13SOf0eurBzMR7osntwOTzgBZVs2fmQQ99dlHTAFHt_H7pf9BZTcB4HtxmjS3SVB-yHfne4pGv02y78GZG6rqFXLpXCH5jHOOS35FXrYsZ3z-c5uftytV58Yzerr8vF_IZ5yY1h5Ru1UdAg6krPQCuPsjXIG6cbzVsDDbRlr5yERhjt1cYbaHHWKqzaBgDOycdT7z715SF5sLuQPcboOuzHbCWAEjNlpCkoO6E-9TknbO0-FQvpYAW3R8n2KNkKY58kF_7Dc_W42WHzn_5ntQDVCXjsY_GV7-P4iMlu0cVh-1RS1RKY5MJwXS5gx8jAX1mchow</recordid><startdate>20190821</startdate><enddate>20190821</enddate><creator>Mei-Dan, Omer</creator><creator>Welton, K. Linnea</creator><creator>Kraeutler, Matthew J.</creator><creator>Young, David A.</creator><creator>Raju, Sivashanmugam</creator><creator>Garabekyan, Tigran</creator><general>The Journal of Bone and Joint Surgery, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8363-5647</orcidid><orcidid>https://orcid.org/0000-0002-0331-107</orcidid><orcidid>https://orcid.org/0000-0002-2276-7814</orcidid><orcidid>https://orcid.org/0000-0001-7555-986</orcidid><orcidid>https://orcid.org/0000-0001-9947-6655</orcidid><orcidid>https://orcid.org/0000-0002-5021-9620</orcidid><orcidid>https://orcid.org/0000-0002-0331-107X</orcidid><orcidid>https://orcid.org/0000-0001-7555-986X</orcidid></search><sort><creationdate>20190821</creationdate><title>The CU PAO: A Minimally Invasive, 2-Incision, Interlocking Periacetabular Osteotomy: Technique and Early Results</title><author>Mei-Dan, Omer ; Welton, K. Linnea ; Kraeutler, Matthew J. ; Young, David A. ; Raju, Sivashanmugam ; Garabekyan, Tigran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2099-1536953dee8487385ce2f9e0da8d80f93d3fda84a23d198c5bc93fe7f5e4fd333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetabulum - diagnostic imaging</topic><topic>Acetabulum - surgery</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Colorado</topic><topic>Female</topic><topic>Hip Dislocation - diagnostic imaging</topic><topic>Hip Dislocation - surgery</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minimally Invasive Surgical Procedures - methods</topic><topic>Osteotomy - adverse effects</topic><topic>Osteotomy - methods</topic><topic>Pain Measurement</topic><topic>Patient Safety - statistics &amp; numerical data</topic><topic>Postoperative Care - methods</topic><topic>Preoperative Care - methods</topic><topic>Prospective Studies</topic><topic>Radiography - methods</topic><topic>Range of Motion, Articular - physiology</topic><topic>Recovery of Function</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mei-Dan, Omer</creatorcontrib><creatorcontrib>Welton, K. Linnea</creatorcontrib><creatorcontrib>Kraeutler, Matthew J.</creatorcontrib><creatorcontrib>Young, David A.</creatorcontrib><creatorcontrib>Raju, Sivashanmugam</creatorcontrib><creatorcontrib>Garabekyan, Tigran</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and joint surgery. American volume</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mei-Dan, Omer</au><au>Welton, K. Linnea</au><au>Kraeutler, Matthew J.</au><au>Young, David A.</au><au>Raju, Sivashanmugam</au><au>Garabekyan, Tigran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The CU PAO: A Minimally Invasive, 2-Incision, Interlocking Periacetabular Osteotomy: Technique and Early Results</atitle><jtitle>Journal of bone and joint surgery. American volume</jtitle><addtitle>J Bone Joint Surg Am</addtitle><date>2019-08-21</date><risdate>2019</risdate><volume>101</volume><issue>16</issue><spage>1495</spage><epage>1504</epage><pages>1495-1504</pages><issn>0021-9355</issn><eissn>1535-1386</eissn><abstract>The aims of this study were to describe a novel minimally invasive, interlocking periacetabular osteotomy (PAO) for the treatment of hip dysplasia that was developed at our institution and to report on its safety, complications, and early clinical outcomes. This was a prospective longitudinal study of the first 200 consecutive hips that underwent the CU (University of Colorado) PAO, an interlocking osteotomy combining the benefits of the Birmingham interlocking pelvic osteotomy (BIPO) and the Ganz PAO. The technique provides direct visualization of the sciatic nerve during the ischial osteotomy and allows for immediate weight-bearing postoperatively. Demographic characteristics, intraoperative and perioperative parameters, and functional outcomes were documented. All patients underwent hip arthroscopy 3 to 10 days prior to the PAO to address concomitant intra-articular pathology. Mechanical deep venous thrombosis (DVT) prophylaxis was used for 2 weeks postoperatively. Results were stratified to compare the first 100 and the second 100 cases. A total of 161 patients (200 hips) underwent primary PAO; mean follow-up was 20 months (range, 3 to 33 months). The mean patient age at the time of surgery was 29.4 years (range, 13 to 55 years). Females accounted for 89% of the patients included in this study. The average length of stay was 4 days. A concomitant proximal femoral derotational osteotomy was performed in 19 hips. The lateral center-edge angle (LCEA) improved from a mean of 18.8° preoperatively to 31.5° postoperatively (p &lt; 0.001). The mean Non-Arthritic Hip Score (NAHS) improved from 56.0 preoperatively to 89.4 at the 24-month follow-up (p &lt; 0.0001). Paresthesias in the distribution of the lateral femoral cutaneous nerve were common (65% at 2 weeks postoperatively) but resolved in 85% of the patients within the first 6 months. There were no sciatic nerve-related complications, deep infections, or DVTs. The CU PAO enables corrective realignment of symptomatic acetabular dysplasia with direct visualization of the sciatic nerve, early weight-bearing, cosmetic incisions, and good short-term outcomes. Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.</abstract><cop>United States</cop><pub>The Journal of Bone and Joint Surgery, Inc</pub><pmid>31436658</pmid><doi>10.2106/JBJS.19.00005</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8363-5647</orcidid><orcidid>https://orcid.org/0000-0002-0331-107</orcidid><orcidid>https://orcid.org/0000-0002-2276-7814</orcidid><orcidid>https://orcid.org/0000-0001-7555-986</orcidid><orcidid>https://orcid.org/0000-0001-9947-6655</orcidid><orcidid>https://orcid.org/0000-0002-5021-9620</orcidid><orcidid>https://orcid.org/0000-0002-0331-107X</orcidid><orcidid>https://orcid.org/0000-0001-7555-986X</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0021-9355
ispartof Journal of bone and joint surgery. American volume, 2019-08, Vol.101 (16), p.1495-1504
issn 0021-9355
1535-1386
language eng
recordid cdi_proquest_miscellaneous_2335175929
source HEAL-Link subscriptions: Lippincott Williams & Wilkins
subjects Acetabulum - diagnostic imaging
Acetabulum - surgery
Adolescent
Adult
Age Factors
Colorado
Female
Hip Dislocation - diagnostic imaging
Hip Dislocation - surgery
Hospitals, University
Humans
Longitudinal Studies
Male
Middle Aged
Minimally Invasive Surgical Procedures - methods
Osteotomy - adverse effects
Osteotomy - methods
Pain Measurement
Patient Safety - statistics & numerical data
Postoperative Care - methods
Preoperative Care - methods
Prospective Studies
Radiography - methods
Range of Motion, Articular - physiology
Recovery of Function
Severity of Illness Index
Sex Factors
Treatment Outcome
Young Adult
title The CU PAO: A Minimally Invasive, 2-Incision, Interlocking Periacetabular Osteotomy: Technique and Early Results
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T00%3A31%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20CU%20PAO:%20A%20Minimally%20Invasive,%202-Incision,%20Interlocking%20Periacetabular%20Osteotomy:%20Technique%20and%20Early%20Results&rft.jtitle=Journal%20of%20bone%20and%20joint%20surgery.%20American%20volume&rft.au=Mei-Dan,%20Omer&rft.date=2019-08-21&rft.volume=101&rft.issue=16&rft.spage=1495&rft.epage=1504&rft.pages=1495-1504&rft.issn=0021-9355&rft.eissn=1535-1386&rft_id=info:doi/10.2106/JBJS.19.00005&rft_dat=%3Cproquest_cross%3E2335175929%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2099-1536953dee8487385ce2f9e0da8d80f93d3fda84a23d198c5bc93fe7f5e4fd333%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2335175929&rft_id=info:pmid/31436658&rfr_iscdi=true