Altered expression of nuclear factor of activated T cells, forkhead box P3, and immune‐suppressive genes in regulatory T cells of generalized vitiligo patients

The study was aimed to analyze expression of nuclear factor of activated T cells (NFATs), forkhead box P3 (FOXP3), and their associated genes (sCTLA4, flCTLA4, IL10, TGFB, IL2, IL4, CD25) in regulatory T cells (Tregs) of 48 generalized vitiligo (GV) patients and 45 unaffected controls. The transcrip...

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Bibliographic Details
Published in:Pigment cell and melanoma research 2020-07, Vol.33 (4), p.566-578
Main Authors: Giri, Prashant S., Dwivedi, Mitesh, Laddha, Naresh C., Begum, Rasheedunnisa, Bharti, Ankit H.
Format: Article
Language:English
Subjects:
active vitiligo
CD25 antigen
forkhead box P3
Forkhead protein
Foxp3 protein
generalized vitiligo
Genes
Genotypes
Immunoregulation
induced tregs
Interleukin 1
Interleukin 10
Interleukin 2
Interleukin 4
Lymphocytes
mRNA expression
NF-AT protein
nuclear factor of activated T cells
Pathogenesis
promoter polymorphisms
Proteins
regulatory T cells
stable vitiligo
Transcription factors
Transforming growth factor-b
Vitiligo
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Summary:The study was aimed to analyze expression of nuclear factor of activated T cells (NFATs), forkhead box P3 (FOXP3), and their associated genes (sCTLA4, flCTLA4, IL10, TGFB, IL2, IL4, CD25) in regulatory T cells (Tregs) of 48 generalized vitiligo (GV) patients and 45 unaffected controls. The transcripts of NFATC1 to NFATC4, FOXP3, IL10, flCTLA4 (p  G), and rs2232365(A > G)] revealed significantly decreased FOXP3 protein levels in patients' Tregs with susceptible AA, GG, and GG genotypes (p 
ISSN:1755-1471
1755-148X
DOI:10.1111/pcmr.12862