Right ventricular end-systolic remodeling index in the assessment of pediatric pulmonary arterial hypertension. The European Pediatric Pulmonary Vascular Disease Network (EPPVDN)

Background Echocardiographic determination of the right ventricular end-systolic remodeling index (RVES RI) has clinical value for the assessment of pulmonary hypertension (PH) in adults. We aim to determine RVES RI values in pediatric PH and to correlate RVES RI data with echocardiographic variable...

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Bibliographic Details
Published in:Pediatric research 2020-08, Vol.88 (2), p.285-292
Main Authors: Koestenberger, Martin, Avian, Alexander, Chouvarine, Phillippe, Gamillscheg, Andreas, Cvirn, Gerhard, Schweintzger, Sabrina, Kurath-Koller, Stefan, Cantinotti, Massimiliano, Hohmann, Dagmar, Hansmann, Georg
Format: Article
Language:English
Subjects:
Clinical Research Article
Hypertension
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Pulmonary arteries
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Summary:Background Echocardiographic determination of the right ventricular end-systolic remodeling index (RVES RI) has clinical value for the assessment of pulmonary hypertension (PH) in adults. We aim to determine RVES RI values in pediatric PH and to correlate RVES RI data with echocardiographic variables and NYHA functional class (FC). Methods Prospective echocardiography study in 49 children with PH. The 49 matched control subjects were chosen from 123 healthy children used to construct pediatric normal reference values. The associations with invasive hemodynamic variables were also investigated in a validation cohort of 12 PH children and matched controls. Results RVES RI was increased in children with PH vs. healthy controls (1.45 ± 0.16 vs. 1.16 ± 0.06; p  
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-020-0748-2