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Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort
Background The causal relationship between asthma and gastroesophageal reflux disease (GERD) is unknown in children. Methods The Korean Health Insurance Review and Assessment Service-National Sample Cohort 2002–2013 was used. The population age
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| Published in: | Pediatric research 2020-08, Vol.88 (2), p.320-324 |
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| container_end_page | 324 |
| container_issue | 2 |
| container_start_page | 320 |
| container_title | Pediatric research |
| container_volume | 88 |
| creator | Kim, So Young Kim, Hye-Rim Min, Chanyang Oh, Dong Jun Park, Bumjung Choi, Hyo Geun |
| description | Background
The causal relationship between asthma and gastroesophageal reflux disease (GERD) is unknown in children.
Methods
The Korean Health Insurance Review and Assessment Service-National Sample Cohort 2002–2013 was used. The population age |
| doi_str_mv | 10.1038/s41390-020-0749-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2336245511</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2336245511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-f3976f16f002e7a94a9d760c6256f543b01e58f53eb90ffa81fbee21b7b54fa23</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7rj6A7xIwIuX1nx2Ot50XVdhQVjWc0h3V2aypJMx6Wbwtj_dNDMqCO4hhKp68lbgQeglJW8p4d27IijXpCGsHiV0Qx-hDZW8VkKox2hDCKcN17o7Q89KuSOECtmJp-iMU824pnKD7j_60WcYZp-iDdiWkgZv1wr3MB8AIr66vPmEbRzrcN5NFvuIh50PY4b4Hs-HhEOKWz8vo18TXAohHZplj8vagoKX4uMWWxztaUmx0z4AHtIu5fk5euJsKPDidJ-j758vby--NNffrr5efLhuBkHI3DiuVeto6whhoKwWVo-qJUPLZOuk4D2hIDsnOfSaOGc76noARnvVS-Es4-fozTF3n9OPBcpsJl8GCMFGSEsxjPOWCSkprejrf9C7tOT680oJ1aqWac0eppiqYrQglaJHasiplAzO7LOfbP5pKDGrRHOUaKpEs0o06_5Xp-Sln2D88-K3tQqwI1DqKG4h_139_9RfvoqniQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2427390940</pqid></control><display><type>article</type><title>Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort</title><source>Springer Nature</source><creator>Kim, So Young ; Kim, Hye-Rim ; Min, Chanyang ; Oh, Dong Jun ; Park, Bumjung ; Choi, Hyo Geun</creator><creatorcontrib>Kim, So Young ; Kim, Hye-Rim ; Min, Chanyang ; Oh, Dong Jun ; Park, Bumjung ; Choi, Hyo Geun</creatorcontrib><description>Background
The causal relationship between asthma and gastroesophageal reflux disease (GERD) is unknown in children.
Methods
The Korean Health Insurance Review and Assessment Service-National Sample Cohort 2002–2013 was used. The population age <15 years was selected. In study I, 86,096 asthmatic children were 1:1 matched with 86,096 control I participants. In study II, 532 GERD children were 1:2 matched with 1064 control II participants. The stratified Cox proportional hazard ratios for GERD in patients with asthma (study I) and asthma in patients with GERD (study II) were analyzed.
Results
In total, 0.7% (583/86,096) of the asthma group and 0.5% (430/86,096) of the control I group had GERD (
P
< 0.001). The asthma group demonstrated a 1.36 times higher HR for GERD than the control I group (95% CI = 1.20–1.54,
P
< 0.001). Subgroup analyses according to age and sex showed consistent results. In total, 15.0% (80/532) of the GERD group and 10.0% (106/1,064) of the control II group had asthma (
P
< 0.001). The GERD group showed a 1.62-fold higher HR for asthma than the control II group (95% CI = 1.21–2.18,
P
< 0.001).
Conclusion
GERD and asthma demonstrated a bidirectional relationship in children.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-020-0749-1</identifier><identifier>PMID: 31923915</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Asthma ; Gastroesophageal reflux ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Population Study Article</subject><ispartof>Pediatric research, 2020-08, Vol.88 (2), p.320-324</ispartof><rights>International Pediatric Research Foundation, Inc 2020</rights><rights>International Pediatric Research Foundation, Inc 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-f3976f16f002e7a94a9d760c6256f543b01e58f53eb90ffa81fbee21b7b54fa23</citedby><cites>FETCH-LOGICAL-c400t-f3976f16f002e7a94a9d760c6256f543b01e58f53eb90ffa81fbee21b7b54fa23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31923915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, So Young</creatorcontrib><creatorcontrib>Kim, Hye-Rim</creatorcontrib><creatorcontrib>Min, Chanyang</creatorcontrib><creatorcontrib>Oh, Dong Jun</creatorcontrib><creatorcontrib>Park, Bumjung</creatorcontrib><creatorcontrib>Choi, Hyo Geun</creatorcontrib><title>Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
The causal relationship between asthma and gastroesophageal reflux disease (GERD) is unknown in children.
Methods
The Korean Health Insurance Review and Assessment Service-National Sample Cohort 2002–2013 was used. The population age <15 years was selected. In study I, 86,096 asthmatic children were 1:1 matched with 86,096 control I participants. In study II, 532 GERD children were 1:2 matched with 1064 control II participants. The stratified Cox proportional hazard ratios for GERD in patients with asthma (study I) and asthma in patients with GERD (study II) were analyzed.
Results
In total, 0.7% (583/86,096) of the asthma group and 0.5% (430/86,096) of the control I group had GERD (
P
< 0.001). The asthma group demonstrated a 1.36 times higher HR for GERD than the control I group (95% CI = 1.20–1.54,
P
< 0.001). Subgroup analyses according to age and sex showed consistent results. In total, 15.0% (80/532) of the GERD group and 10.0% (106/1,064) of the control II group had asthma (
P
< 0.001). The GERD group showed a 1.62-fold higher HR for asthma than the control II group (95% CI = 1.21–2.18,
P
< 0.001).
Conclusion
GERD and asthma demonstrated a bidirectional relationship in children.</description><subject>Asthma</subject><subject>Gastroesophageal reflux</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Population Study Article</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU2LFDEQhoMo7rj6A7xIwIuX1nx2Ot50XVdhQVjWc0h3V2aypJMx6Wbwtj_dNDMqCO4hhKp68lbgQeglJW8p4d27IijXpCGsHiV0Qx-hDZW8VkKox2hDCKcN17o7Q89KuSOECtmJp-iMU824pnKD7j_60WcYZp-iDdiWkgZv1wr3MB8AIr66vPmEbRzrcN5NFvuIh50PY4b4Hs-HhEOKWz8vo18TXAohHZplj8vagoKX4uMWWxztaUmx0z4AHtIu5fk5euJsKPDidJ-j758vby--NNffrr5efLhuBkHI3DiuVeto6whhoKwWVo-qJUPLZOuk4D2hIDsnOfSaOGc76noARnvVS-Es4-fozTF3n9OPBcpsJl8GCMFGSEsxjPOWCSkprejrf9C7tOT680oJ1aqWac0eppiqYrQglaJHasiplAzO7LOfbP5pKDGrRHOUaKpEs0o06_5Xp-Sln2D88-K3tQqwI1DqKG4h_139_9RfvoqniQ</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Kim, So Young</creator><creator>Kim, Hye-Rim</creator><creator>Min, Chanyang</creator><creator>Oh, Dong Jun</creator><creator>Park, Bumjung</creator><creator>Choi, Hyo Geun</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort</title><author>Kim, So Young ; Kim, Hye-Rim ; Min, Chanyang ; Oh, Dong Jun ; Park, Bumjung ; Choi, Hyo Geun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-f3976f16f002e7a94a9d760c6256f543b01e58f53eb90ffa81fbee21b7b54fa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Asthma</topic><topic>Gastroesophageal reflux</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Population Study Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, So Young</creatorcontrib><creatorcontrib>Kim, Hye-Rim</creatorcontrib><creatorcontrib>Min, Chanyang</creatorcontrib><creatorcontrib>Oh, Dong Jun</creatorcontrib><creatorcontrib>Park, Bumjung</creatorcontrib><creatorcontrib>Choi, Hyo Geun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, So Young</au><au>Kim, Hye-Rim</au><au>Min, Chanyang</au><au>Oh, Dong Jun</au><au>Park, Bumjung</au><au>Choi, Hyo Geun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>88</volume><issue>2</issue><spage>320</spage><epage>324</epage><pages>320-324</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
The causal relationship between asthma and gastroesophageal reflux disease (GERD) is unknown in children.
Methods
The Korean Health Insurance Review and Assessment Service-National Sample Cohort 2002–2013 was used. The population age <15 years was selected. In study I, 86,096 asthmatic children were 1:1 matched with 86,096 control I participants. In study II, 532 GERD children were 1:2 matched with 1064 control II participants. The stratified Cox proportional hazard ratios for GERD in patients with asthma (study I) and asthma in patients with GERD (study II) were analyzed.
Results
In total, 0.7% (583/86,096) of the asthma group and 0.5% (430/86,096) of the control I group had GERD (
P
< 0.001). The asthma group demonstrated a 1.36 times higher HR for GERD than the control I group (95% CI = 1.20–1.54,
P
< 0.001). Subgroup analyses according to age and sex showed consistent results. In total, 15.0% (80/532) of the GERD group and 10.0% (106/1,064) of the control II group had asthma (
P
< 0.001). The GERD group showed a 1.62-fold higher HR for asthma than the control II group (95% CI = 1.21–2.18,
P
< 0.001).
Conclusion
GERD and asthma demonstrated a bidirectional relationship in children.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>31923915</pmid><doi>10.1038/s41390-020-0749-1</doi><tpages>5</tpages></addata></record> |
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| subjects | Asthma Gastroesophageal reflux Medicine Medicine & Public Health Pediatric Surgery Pediatrics Population Study Article |
| title | Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort |
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