Gold nanozyme: Biosensing and therapeutic activities

The utilization of AuNPs in therapeutic applications has been accelerated by discovering their catalytic activity consistent with the activity of natural enzymes. However, to reduce unwanted activities, it is imperative to fully understand their catalytic mechanisms to increase efficiency and safety...

Full description

Saved in:
Bibliographic Details
Published in:Materials Science & Engineering C 2020-03, Vol.108, p.110422-110422, Article 110422
Main Authors: Sharifi, Majid, Hosseinali, Sara Haji, Yousefvand, Pedram, Salihi, Abbas, Shekha, Mudhir Sabir, Aziz, Falah Mohammad, JouyaTalaei, Amir, Hasan, Anwarul, Falahati, Mojtaba
Format: Article
Language:English
Subjects:
Biosensing
Biosensors
Biotechnology
Catalytic activity
Colorimetry
Enzymatic activity
Enzyme mimetics
Gold nanozymes
Hydrogen peroxide
Materials science
Neurodegenerative diseases
Nucleic acids
Therapeutic applications
Therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The utilization of AuNPs in therapeutic applications has been accelerated by discovering their catalytic activity consistent with the activity of natural enzymes. However, to reduce unwanted activities, it is imperative to fully understand their catalytic mechanisms to increase efficiency and safety. Therefore, along with other reports, we aimed to classify the enzymatic activity of Au nanozymes based on recent advance in their applications in biosensing and therapeutic activities. The results of the reported experiments indicate that the Au nanozymes can be used in biosensing of a wide range of agents such as molecule (H2O2 and glucose), ions, nucleic acids, proteins, cells, and pathogens. Furthermore, they can be used as potential candidates in inhibition of neurodegenerative diseases, cancer therapy, and antibacterial activities. Biosensing and therapeutic activities are generally based on colorimetric assays and the controlling the ROS level in the targeted cells, respectively. Finally, a brief explanation of the current challenges of the Au nanozymes in biomedical approaches was discussed. Indeed, this review holds a great promise in understanding the Au nanozymes properties and their development in biotechnology, medicine, and related industries. •Biosensing based on gold-nanozymes•Molecule and ion sensing•Nucleic acid and protein sensing•Cells and pathogen sensing•Protein sensing•Cells and pathogens sensing•Therapeutic activaties based on gold-nanozymes
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2019.110422