Upregulation of VEGF-A and correlation between VEGF-A and FLT-1 expressions in Iranian multiple sclerosis patients

Multiple sclerosis (MS) is among the most common diseases affecting brain and spinal cord. MS progression is characterized by breakdown of blood brain barrier which leads to increased vascular permeability and angiogenesis. Consequently, vascular endothelial growth factor A (VEGF) and its receptors...

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Bibliographic Details
Published in:Neurological sciences 2020-06, Vol.41 (6), p.1459-1465
Main Authors: Azimi, Ghazaleh, Ranjbaran, Fatemeh, Arsang-Jang, Shahram, Ghafouri-Fard, Soudeh, Mazdeh, Mehrdokht, Sayad, Arezou, Taheri, Mohammad
Format: Article
Language:English
Subjects:
Adult
Angiogenesis
Blood-brain barrier
Case-Control Studies
Female
Flt1 protein
Gene Expression
Humans
Iran
Kinases
Male
Medicine
Medicine & Public Health
Molecular modelling
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - blood
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Permeability
Protein-tyrosine kinase
Psychiatry
Spinal cord
Up-Regulation
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor Receptor-1 - blood
Vascular Endothelial Growth Factor Receptor-1 - genetics
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Summary:Multiple sclerosis (MS) is among the most common diseases affecting brain and spinal cord. MS progression is characterized by breakdown of blood brain barrier which leads to increased vascular permeability and angiogenesis. Consequently, vascular endothelial growth factor A (VEGF) and its receptors are considered to be important components of MS progression. VEGFA and fms-related tyrosine kinase 1 ( FLT1 ) play important roles in various aspects of MS. In this study, we investigated the relationship between these genes and MS. For this purpose, the expression levels of VEGFA and FLT1 were measured in the blood of 50 relapsing-remitting MS (RR-MS) patients and 50 healthy individuals using TaqMan quantitative real-time PCR. A significant upregulation of VEGFA expression was observed among MS patients compared with controls ( p  = 0.04). However, the difference in FLT1 gene expression between study groups was insignificant ( p  = 0.947). In addition, there was a significant positive correlation between VEGFA and FLT1 genes expressions ( r  = 0.769, p  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-019-04234-2