Outcome of ICSI pregnancies with spontaneous loss of a co‐twin compared with singleton ICSI pregnancies: Single center experience

• Published in: The journal of obstetrics and gynaecology research 2020-03, Vol.46 (3), p.445-450
• Main Authors: Uysal, Nihal Ş., Gülümser, Çağrı, Bilgin Yanık, Filiz F., Önalan, Göğşen, Zeyneloğlu, Hulusi B.
• Format: Article
• Language: English
• Subjects: Abortion, Spontaneous; Adult; Birth weight; Diabetes mellitus; Female; fertilization in vitro; fetal death; Gestational Age; Humans; Infant, Newborn; intracytoplasmic sperm injections; Maternal Age; Middle Aged; multiple pregnancy; Neonates; Perinatal Mortality; Placenta; Pregnancy; Pregnancy Outcome; Pregnancy, Twin; Premature birth; Small-for-gestational age; Sperm Injections, Intracytoplasmic; Statistical analysis; Young Adult
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.14177

Aim To compare the outcome of intracytoplasmic sperm injection (ICSI) pregnancies complicated by spontaneous loss of a dichorionic co‐twin with that of singleton ICSI pregnancies. Methods The study group included dichorionic ICSI pregnancies with co‐twin loss (n = 33) and the control group included ICSI pregnancies with a singleton from the beginning (n = 327). Primary outcome measures were obstetric complications, including preterm delivery, newborn small for gestational age, gestational diabetes, gestational hypertensive disorders and abruptio placenta; admission to neonatal intensive care unit (NICU) and perinatal mortality observed in the study and control groups. Statistical analysis was performed using spss for Windows, version 22.0. Results In the study group, there were 26 cases of first trimester (early) and 7 cases of second or third trimester (late) co‐twin losses. Mean gestational age at delivery and mean birth weight were significantly lower in the whole study group compared to control (P