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Rethinking the pragmatic systems biology and systems-theoretical biology divide: Toward a complexity-inspired epistemology of systems biomedicine

This paper examines some methodological and epistemological issues underlying the ongoing “artificial” divide between pragmatic-systems biology and systems-theoretical biology. The pragmatic systems view of biology has encountered problems and constraints on its explanatory power because pragmatic s...

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Published in:Medical hypotheses 2019-10, Vol.131, p.109316-109316, Article 109316
Main Author: Kesić, Srdjan
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Language:English
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description This paper examines some methodological and epistemological issues underlying the ongoing “artificial” divide between pragmatic-systems biology and systems-theoretical biology. The pragmatic systems view of biology has encountered problems and constraints on its explanatory power because pragmatic systems biologists still tend to view systems as mere collections of parts, not as “emergent realities” produced by adaptive interactions between the constituting components. As such, they are incapable of characterizing the higher-level biological phenomena adequately. The attempts of systems-theoretical biologists to explain these “emergent realities” using mathematics also fail to produce satisfactory results. Given the increasing strategic importance of systems biology, both from theoretical and research perspectives, we suggest that additional epistemological and methodological insights into the possibility of further integration between traditional experimental studies and complex modeling are required. This integration will help to improve the currently underdeveloped pragmatic-systems biology and system-theoretical biology. The “epistemology of complexity,” I contend, acts as a glue that connects and integrates different and sometimes opposing viewpoints, perspectives, streams, and practices, thus maintaining intellectual and research coherence of systems research of life. It allows scientists to shift the focus from traditional experimental research to integrated, modeling-based holistic practices capable of providing a comprehensive knowledge of organizing principles of living systems. It also opens the possibility of the development of new practical and theoretical foundations of systems biology to build a better understanding of complex organismic functions.
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subjects Complex biological systems
Complexity
Computer Simulation
Cybernetics
Epistemology of complexity
Forecasting
Humans
Knowledge
Models, Theoretical
Philosophy
Second-order cybernetics
Systems Analysis
Systems biology
Systems Biology - classification
Systems Biology - methods
title Rethinking the pragmatic systems biology and systems-theoretical biology divide: Toward a complexity-inspired epistemology of systems biomedicine
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