Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model

The aim of this study was to investigate whether concomitant treatment of dutasteride and sildenafil could prevent structural changes in the penis of a BPH rodent model. Thirty-two adult male rats were divided into the following groups: Ctrl, untreated control rats; BPH, untreated spontaneously hype...

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Bibliographic Details
Published in:The aging male 2020-12, Vol.23 (5), p.1009-1015
Main Authors: Da Silva, Marcello H. A., Medeiros, Jorge L., Costa, Waldemar S., Sampaio, Francisco J. B., De Souza, Diogo B.
Format: Article
Language:English
Subjects:
5-alpha Reductase Inhibitors
Aging
Animals
Benign prostatic hyperplasia
Disease Models, Animal
Drug therapy
dutasteride
Dutasteride - therapeutic use
Erectile dysfunction
Genital diseases
Humans
Hyperplasia
Hypertension
Male
Morphology
Penis
Prostatic Hyperplasia - drug therapy
Rats
Rodents
sildenafil
Sildenafil Citrate
Smooth muscle
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Summary:The aim of this study was to investigate whether concomitant treatment of dutasteride and sildenafil could prevent structural changes in the penis of a BPH rodent model. Thirty-two adult male rats were divided into the following groups: Ctrl, untreated control rats; BPH, untreated spontaneously hypertensive rats (SHRs); BPH + D, SHRs treated with dutasteride; and BPH + DS, SHRs treated with dutasteride and sildenafil. All treatments were performed during 40 days, following which the penises were collected for histomorphometrical analysis. The results were compared via one-way ANOVA with Bonferroni's post-test, considering p values
ISSN:1368-5538
1473-0790
DOI:10.1080/13685538.2019.1653839