Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

Myokines are molecules produced and secreted by skeletal muscle to act in an auto‐, para‐ and endocrine manner to alter physiological function of target tissues. The growing number of effects of myokines on metabolism of distant tissues provides a compelling case for crosstalk between skeletal muscl...

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Bibliographic Details
Published in:Acta Physiologica 2020-02, Vol.228 (2), p.e13367-n/a
Main Authors: Das, Dibash K., Graham, Zachary A., Cardozo, Christopher P.
Format: Article
Language:English
Subjects:
interleukin‐15
Metabolic disorders
Metabolism
meteorin‐like
Musculoskeletal system
myonectin
Myostatin
Skeletal muscle
Therapeutic applications
β‐aminoisobutyric acid
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Summary:Myokines are molecules produced and secreted by skeletal muscle to act in an auto‐, para‐ and endocrine manner to alter physiological function of target tissues. The growing number of effects of myokines on metabolism of distant tissues provides a compelling case for crosstalk between skeletal muscle and other tissues and organs to regulate metabolic homoeostasis. In this review, we summarize and discuss the current knowledge regarding the impact on metabolism of several canonical and recently identified myokines. We focus specifically on myostatin, β‐aminoisobutyric acid, interleukin‐15, meteorin‐like and myonectin, and discuss how these myokines are induced and regulated as well as their overall function. We also review how these myokines may serve as potential prognostic biomarkers that reflect whole‐body metabolism and how they may be attractive therapeutic targets for treating muscle and metabolic diseases.
ISSN:1748-1708
1748-1716
DOI:10.1111/apha.13367