Vanadium Compounds as Biocatalyst Models

Peroxidovanadium(V) and oxidovanadium(IV) compounds have been tested as peroxidase-similar compounds. Their catalytic performance was tested on phenol red and pyrogallol substrates. Bromination kinetic studies revealed Michaelis-Menten behavior with respect to phenol red for both complexes. Catalyti...

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Bibliographic Details
Published in:Biological trace element research 2020-06, Vol.195 (2), p.725-731
Main Authors: Parente, Juliana E., Williams, Patricia A. M., Ferrer, Evelina G.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biotechnology
Bromination
Bromphenol Blue - chemical synthesis
Bromphenol Blue - chemistry
Catalysis
Coordination Complexes - chemistry
Kinetics
Life Sciences
Molecular Structure
Nutrition
Oncology
Oxidation-Reduction
Peroxidase
Phenols
Pyrogallol
Pyrogallol - chemistry
Reaction kinetics
Substrates
Vanadium
Vanadium compounds
Vanadium Compounds - chemistry
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Summary:Peroxidovanadium(V) and oxidovanadium(IV) compounds have been tested as peroxidase-similar compounds. Their catalytic performance was tested on phenol red and pyrogallol substrates. Bromination kinetic studies revealed Michaelis-Menten behavior with respect to phenol red for both complexes. Catalytic efficiency is ~ 10 4 M −1 min −1 . Both vanadium complexes showed the capacity to oxidize pyrogallol, but only the oxidovanadium (IV) complex follows Michaelis-Menten kinetics with respect to this substrate ( K m = 1.05 × 10 -3 M). Peroxidovanadium(V) complex displayed a more complex mechanism, and further studies became necessary to elucidate it. The structure-activity relationship was also assessed.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-019-01874-5