Therapeutic potentials of curcumin in the treatment of glioblstoma

• Published in: European journal of medicinal chemistry 2020-02, Vol.188, p.112040-112040, Article 112040
• Main Authors: Shabaninejad, Zahra, Pourhanifeh, Mohammad Hossein, Movahedpour, Ahmad, Mottaghi, Reza, Nickdasti, Ali, Mortezapour, Erfan, Shafiee, Alimohammad, Hajighadimi, Sarah, Moradizarmehri, Sanaz, Sadeghian, Mohammad, Mousavi, Seyed Mojtaba, Mirzaei, Hamed
• Format: Article
• Language: English
• Subjects: Curcumin; Glioblastoma; Therapy
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2020.112040

Glioblastoma multiforme (GBM), a greatly aggressive malignancy of the brain, is correlated with a poor prognosis and low rate of survival. Up to now, chemotherapy and radiation therapy after surgical approaches have been the treatments increasing the survival rates. The low efficacy of mentioned therapies as well as their side-effects has forced researchers to explore an appropriate alternative or complementary treatment for glioblastoma. In experimental models, it has been shown that curcumin has therapeutic potentials to fight against GBM. Given that curcumin has pharmacological effects against cancer stem cells, as major causes of resistance to therapy in glioblastoma cells. Moreover, it has been showed that curcumin exerts its therapeutic effects on GBM cells via affecting on apoptosis, oxidant system, and inflammatory pathways. Curcumin would possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as therapeutic agent in the treatment of GBM. [Display omitted] •Glioblastoma multiforme (GBM) is known as a greatly aggressive malignancy of the brain.•Curcumin has therapeutic potentials to fight against GBM.•Curcumin exerts its therapeutic effects against GBM cells via antioxidant and anti-inflammatory activities.