Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive–Compulsive Disorder Rats

The present study aims to discuss the effect of escitalopram in glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) levels, and 5-Hydroxytryptamine (5-HT) in obsessive–compulsive disorder rats. A total of 42 rats were divided into three groups randomly: contr...

Full description

Saved in:
Bibliographic Details
Published in:Cellular and molecular neurobiology 2020-08, Vol.40 (6), p.991-997
Main Authors: Guo, Hui-Rong, Huang, Bai-Ling, Wang, Ya-Li, Zhang, Yan-Yan, Ma, Quan-Gang, Lv, Pei-Pei, Ren, Yu-Ming
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Cell Biology
Citalopram
Citalopram - pharmacology
Electrochemistry
Enzyme-linked immunosorbent assay
Glial cell line-derived neurotrophic factor
Glial Cell Line-Derived Neurotrophic Factor - blood
High-performance liquid chromatography
Neurobiology
Neuronal-glial interactions
Neurosciences
Obsessive-Compulsive Disorder - blood
Original Research
Rats, Wistar
Serotonin - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study aims to discuss the effect of escitalopram in glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) levels, and 5-Hydroxytryptamine (5-HT) in obsessive–compulsive disorder rats. A total of 42 rats were divided into three groups randomly: control group ( n  = 14), model group ( n  = 14) (obsessive–compulsive disorder group), and escitalopram group ( n  = 14) (model + obsessive–compulsive disorder group + escitalopram treatment). The open-field method was used to test the rat behavior, enzyme-linked immunosorbent assay (ELISA) was used to determine the serum GDNF and BDNF levels. In addition, Western blot was used to determine the brain tissue protein levels of GDNF and BDNF and high-performance liquid chromatography + electrochemistry method to determine the 5-HT level of brain tissue. Visiting place was changed, rotational frequency and fixed duration enhanced in escitalopram group compared to model group ( P  
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-020-00788-4