Role of GABAA Receptors in the Mechanism of In Vivo Psychotropic Activity of Amitriptyline in Rats

Standard water-reinforced drug discrimination model was employed to train Wistar rats to discriminate the intraperitoneal injections of tricyclic antidepressant amitriptyline (5.4 mg/kg) and physiological saline. To examine the role of GABA A receptors in psychotropic action of amitriptyline, the su...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020, Vol.168 (3), p.341-344
Main Authors: Korolev, A. O., Kalinina, T. S., Volkova, A. V., Shimshirt, A. A., Kudryashov, N. V., Voronina, T. A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Pathology
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Summary:Standard water-reinforced drug discrimination model was employed to train Wistar rats to discriminate the intraperitoneal injections of tricyclic antidepressant amitriptyline (5.4 mg/kg) and physiological saline. To examine the role of GABA A receptors in psychotropic action of amitriptyline, the substitution tests were performed with muscimol (0.1-1.0 mg/kg) and pregnenolone (30-50 mg/kg). Similar tests were carried out with amitriptyline interoceptive antagonists bicuculline (1 mg/kg), flumazenil (15 mg/kg), finasteride (5 mg/kg), and indomethacin (7.5 mg/kg). The study showed that interoceptive effects of amitriptyline depend on functional activity of GABA A receptors but not on the neurosteroid site of GABA A receptor complex.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04704-0