Synthesis and Metabolism of Nitric Oxide (NO) in Chicken Embryos and in the Blood of Adult Chicken

In chicken embryos, nitric oxide (NO) is accumulated in the pool of NO donors: S-nitrosothiols, nitrosyl-iron complexes, high-molecular-weight nitro-compounds. Oxidation of NO to nitrate occurs with different intensity in the embryos of different chicken breeds. In some embryos, NO donors accumulate...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020, Vol.168 (3), p.321-325
Main Authors: Titov, V. Yu, Dolgorukova, A. M., Vertiprakhov, V. G., Ivanova, A. V., Osipov, A. N., Slesarenko, N. A., Kochish, I. I.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Cell Biology
Embryonic development
Ethylenediaminetetraacetic acid
Internal Medicine
Laboratory Medicine
Nitric oxide
Pathology
Physiological aspects
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Summary:In chicken embryos, nitric oxide (NO) is accumulated in the pool of NO donors: S-nitrosothiols, nitrosyl-iron complexes, high-molecular-weight nitro-compounds. Oxidation of NO to nitrate occurs with different intensity in the embryos of different chicken breeds. In some embryos, NO donors accumulate almost without oxidation. Stable concentration of NO donors and nitrate in the blood of adult chicken is a result of dynamic equilibrium between NO synthesis and elimination (oxidation, consumption by other tissues, and excretion). As NO oxidation occurs mainly not in the blood, but in other tissues, decomposition of NO donors and NO oxidation are determined the properties of these tissues, in particular, the presence of physiological targets of NO, rather than spontaneous processes. Hence, evaluation of the intensity of NO metabolism is important for prediction of the efficiency of preparations containing NO donors and stimulators of its synthesis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04700-4