L-linalool exerts a neuroprotective action on hemiparkinsonian rats

• Published in: Naunyn-Schmiedeberg's archives of pharmacology 2020-06, Vol.393 (6), p.1077-1088
• Main Authors: de Lucena, Jalles Dantas, Gadelha-Filho, Carlos Vinicius Jataí, da Costa, Roberta Oliveira, de Araújo, Dayane Pessoa, Lima, Francisco Arnaldo Viana, Neves, Kelly Rose Tavares, de Barros Viana, Glauce Socorro
• Format: Article
• Language: English
• Subjects: Animal models; Antioxidants; Apomorphine; Aroma; Benzodiazepines; Biomedical and Life Sciences; Biomedicine; Essential oils; Immunohistochemistry; Inflammation; Linalool; Movement disorders; Neostriatum; Neurodegenerative diseases; Neuroprotection; Neurosciences; Original Article; Parkinson's disease; Pharmacology/Toxicology; Prefrontal cortex; Rodents; γ-Aminobutyric acid
• ISSN: 0028-1298; 1432-1912
• DOI: 10.1007/s00210-019-01793-1

Linalool (LIN) is a monoterpene, responsible for the aroma of essential oils in some species. It presents a sedative and anxiolytic potential, enhancing GABAergic currents and behaving as a benzodiazepine-type of drug. The objectives of the present work were to study the neuroprotective effects of LIN on a model of Parkinson’s disease. For that, male Wistar rats were divided into the following groups: sham-operated (SO), 6-OHDA-lesioned, and 6-OHDA-lesioned and treated with LIN (25, 50, and 100 mg/kg, p.o.) for 2 weeks. Afterwards, the animals were subjected to behavioral tests (apomorphine-induced rotations, open field, and forced swimming tests). Then, the animals were euthanized, and the striatum, hippocampus, and prefrontal cortex were processed for neurochemistry (nitrite and lipoperoxidation measurements) and immunohistochemistry (TH and DAT) assays. The results were analyzed by ANOVA and Tukey’s test for multiple comparisons and considered significant at p