L-linalool exerts a neuroprotective action on hemiparkinsonian rats

Linalool (LIN) is a monoterpene, responsible for the aroma of essential oils in some species. It presents a sedative and anxiolytic potential, enhancing GABAergic currents and behaving as a benzodiazepine-type of drug. The objectives of the present work were to study the neuroprotective effects of L...

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Published in:Naunyn-Schmiedeberg's archives of pharmacology 2020-06, Vol.393 (6), p.1077-1088
Main Authors: de Lucena, Jalles Dantas, Gadelha-Filho, Carlos Vinicius Jataí, da Costa, Roberta Oliveira, de Araújo, Dayane Pessoa, Lima, Francisco Arnaldo Viana, Neves, Kelly Rose Tavares, de Barros Viana, Glauce Socorro
Format: Article
Language:English
Subjects:
Animal models
Antioxidants
Apomorphine
Aroma
Benzodiazepines
Biomedical and Life Sciences
Biomedicine
Essential oils
Immunohistochemistry
Inflammation
Linalool
Movement disorders
Neostriatum
Neurodegenerative diseases
Neuroprotection
Neurosciences
Original Article
Parkinson's disease
Pharmacology/Toxicology
Prefrontal cortex
Rodents
γ-Aminobutyric acid
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creator de Lucena, Jalles Dantas
Gadelha-Filho, Carlos Vinicius Jataí
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Lima, Francisco Arnaldo Viana
Neves, Kelly Rose Tavares
de Barros Viana, Glauce Socorro
description Linalool (LIN) is a monoterpene, responsible for the aroma of essential oils in some species. It presents a sedative and anxiolytic potential, enhancing GABAergic currents and behaving as a benzodiazepine-type of drug. The objectives of the present work were to study the neuroprotective effects of LIN on a model of Parkinson’s disease. For that, male Wistar rats were divided into the following groups: sham-operated (SO), 6-OHDA-lesioned, and 6-OHDA-lesioned and treated with LIN (25, 50, and 100 mg/kg, p.o.) for 2 weeks. Afterwards, the animals were subjected to behavioral tests (apomorphine-induced rotations, open field, and forced swimming tests). Then, the animals were euthanized, and the striatum, hippocampus, and prefrontal cortex were processed for neurochemistry (nitrite and lipoperoxidation measurements) and immunohistochemistry (TH and DAT) assays. The results were analyzed by ANOVA and Tukey’s test for multiple comparisons and considered significant at p  
doi_str_mv 10.1007/s00210-019-01793-1
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It presents a sedative and anxiolytic potential, enhancing GABAergic currents and behaving as a benzodiazepine-type of drug. The objectives of the present work were to study the neuroprotective effects of LIN on a model of Parkinson’s disease. For that, male Wistar rats were divided into the following groups: sham-operated (SO), 6-OHDA-lesioned, and 6-OHDA-lesioned and treated with LIN (25, 50, and 100 mg/kg, p.o.) for 2 weeks. Afterwards, the animals were subjected to behavioral tests (apomorphine-induced rotations, open field, and forced swimming tests). Then, the animals were euthanized, and the striatum, hippocampus, and prefrontal cortex were processed for neurochemistry (nitrite and lipoperoxidation measurements) and immunohistochemistry (TH and DAT) assays. The results were analyzed by ANOVA and Tukey’s test for multiple comparisons and considered significant at p  &lt; 0.05. LIN significantly improved the behavioral alterations of the 6-OHDA-lesioned group, as evaluated by the apomorphine-induced rotations, open field, and forced swimming tests. In addition, LIN partially reversed the decreased DA, DOPAC, and HVA contents observed in the 6-OHDA-lesioned striatum. The untreated 6-OHDA group presented increased nitrite contents and lipoperoxidation in all the brain areas studied, and these changes were completely reversed after LIN treatments. Finally, LIN significantly prevented the reduction in TH and DAT expressions demonstrated in the right 6-OHDA-lesioned striatum. 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source Springer Nature
subjects Animal models
Antioxidants
Apomorphine
Aroma
Benzodiazepines
Biomedical and Life Sciences
Biomedicine
Essential oils
Immunohistochemistry
Inflammation
Linalool
Movement disorders
Neostriatum
Neurodegenerative diseases
Neuroprotection
Neurosciences
Original Article
Parkinson's disease
Pharmacology/Toxicology
Prefrontal cortex
Rodents
γ-Aminobutyric acid
title L-linalool exerts a neuroprotective action on hemiparkinsonian rats
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