Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model

Aims To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). Methods Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal mu...

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Bibliographic Details
Published in:Acta diabetologica 2020-06, Vol.57 (6), p.673-679
Main Authors: Chen, Yushu, Zeng, Wen, Chen, Wei, Zhang, Yu, Zhu, Tong, Sun, Jiayu, Liang, Zhigang, Wang, Lei, Yang, Zunyuan, Wu, Bing, Song, Bin, Wang, Fangtong, Liang, Yinan, Gong, Li, Zheng, Jie, Gao, Fabao
Format: Article
Language:English
Subjects:
Animals
Blood flow
Cardiac muscle
Coronary Vessels - diagnostic imaging
Coronary Vessels - pathology
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - pathology
Diabetes Mellitus, Type 2 - physiopathology
Diabetic Angiopathies - diagnosis
Diabetic Angiopathies - pathology
Diabetic Angiopathies - physiopathology
Disease Models, Animal
Female
Gastrocnemius muscle
Heart - diagnostic imaging
Heart - physiopathology
Humans
Hyperemia
Image processing
Internal Medicine
Macaca mulatta
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Microcirculation - physiology
Muscle, Skeletal - blood supply
Muscle, Skeletal - diagnostic imaging
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Musculoskeletal system
Myocardium - pathology
Original Article
Regional Blood Flow
Skeletal muscle
Soleus muscle
Tibialis anterior muscle
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Summary:Aims To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). Methods Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis. Results Eight T2DM monkeys and eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF reserves were found significantly decreased in T2DM during inflation in SOL, GAS and TA muscles (all p  
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-019-01460-0