Emerging roles of HOTAIR in human cancer

Long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is overexpressed in many types of cancers, and substantial evidence has suggested a link between cancers and HOTAIR. In the present study, we reviewed the structure and the corresponding biologic function of HOTAIR to clarify its molecular mec...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2020-06, Vol.121 (5-6), p.3235-3247
Main Authors: Yuan, Chunjue, Ning, Yong, Pan, Yunbao
Format: Article
Language:English
Subjects:
Antisense RNA
Apoptosis
biomarker
Biomarkers
Cancer
Cell proliferation
epithelial‐mesenchymal transformation
HOTAIR
immune signaling
nasopharyngeal carcinoma
Pathogenesis
Ribonucleic acid
RNA
Throat cancer
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Summary:Long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is overexpressed in many types of cancers, and substantial evidence has suggested a link between cancers and HOTAIR. In the present study, we reviewed the structure and the corresponding biologic function of HOTAIR to clarify its molecular mechanism in cancer progression. HOTAIR promotes proliferation, invasion, and migration, and inhibits apoptosis in cancer cells. HOTAIR also participates in the pathogenesis and progression of cancer by regulating inflammation and immune signaling. These findings suggested that HOTAIR is a novel biomarker in human cancers. 1. HOX antisense intergenic RNA (HOTAIR) promotes proliferation, invasion, and migration, and inhibits apoptosis in cancer cells. 2. HOTAIR also participates in the pathogenesis and progression of cancer by regulating inflammation and immune signaling. 3. HOTAIR is a novel biomarker in human cancers.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.29591