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High prevalence of parent‐reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy
Objective To assess sleep problems (prevalence and predictors) in pediatric patients with acute lymphoblastic leukemia (ALL) after the most intensive phase of therapy (induction). Methods Patients (≥2 years) treated according to the Dutch ALL‐11 protocol were included. Sleep was measured using paren...
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| Published in: | Pediatric blood & cancer 2020-04, Vol.67 (4), p.e28165-n/a |
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| container_issue | 4 |
| container_start_page | e28165 |
| container_title | Pediatric blood & cancer |
| container_volume | 67 |
| creator | Steur, Lindsay M. H. Grootenhuis, Martha A. Van Someren, Eus J. W. Van Eijkelenburg, Natasha K. A. Van der Sluis, Inge M. Dors, Natasja Van den Bos, Cor Tissing, Wim J. E. Kaspers, Gertjan J. L. Van Litsenburg, Raphaële R. L. |
| description | Objective
To assess sleep problems (prevalence and predictors) in pediatric patients with acute lymphoblastic leukemia (ALL) after the most intensive phase of therapy (induction).
Methods
Patients (≥2 years) treated according to the Dutch ALL‐11 protocol were included. Sleep was measured using parent‐reports and self‐reports (Children's Sleep Habits Questionnaire; CSHQ) and actigraphy. Parental sleep (Medical Outcome Study Sleep Scale) and distress and parenting problems (Distress Thermometer for Parents) were assessed with questionnaires. Z‐scores were calculated for total CSHQ scores using age‐appropriate scores of healthy Dutch children. The prevalence of sleep problems (defined as a Z‐score > 1) in patients with ALL was compared to healthy children (chi‐square tests). Actigraphic sleep estimates were collected in healthy Dutch children (n = 86, 2‐18 years) for comparison with patients (linear regression). Determinants of parent‐reported child sleep (total CSHQ Z‐score) were identified with regression models.
Results
Responses were collected for 124 patients (response rate 67%), comprising 123 parent‐reports, 34 self‐reports, and 69 actigraphy assessments. Parents reported sleep problems in 38.0% of the patients compared to 15.2% in healthy children (P |
| doi_str_mv | 10.1002/pbc.28165 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2339791736</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2359876336</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3885-61721c8d08340931176c247c312951bb993298572f08227ee2f04950cb7fcd643</originalsourceid><addsrcrecordid>eNp10b9O3TAUBnALtQIKDH0BZKkLHS74TxzbY7lqoRJSGWCOHOeEa-okxnZAd6vUF-AZeRJcLmWo1Mln-J1Px_oQ-kjJMSWEnYTWHjNFa7GFdqmoxEIQKt-9zUTvoA8p3RZaE6G20Q6nuqpEpXbR73N3s8Ihwr3xMFrAU4-DiTDmp1-PEcIUM3Q4eYBQ1NR6GBJ2Iw7QOZOjs0VnV3jCDy6vsLFzBuzXQ1gVbFIuwsP8EwZnsOkzxLLdzTa7acR5BdGE9T563xuf4OD13UPX375eLc8XFz_Ovi-_XCwsV0osaioZtaojildEc0plbVklLadMC9q2WnOmlZCsJ4oxCVCGSgtiW9nbrq74Hjra5JaP3M2QcjO4ZMF7M8I0p4ZxrqWmkteFfvqH3k5zHMt1RQmtZM1f1OeNsnFKKULfhOgGE9cNJc2fZprSTPPSTLGHr4lzO0D3Jv9WUcDJBjw4D-v_JzWXp8tN5DPqL5k8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2359876336</pqid></control><display><type>article</type><title>High prevalence of parent‐reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy</title><source>Wiley</source><creator>Steur, Lindsay M. H. ; Grootenhuis, Martha A. ; Van Someren, Eus J. W. ; Van Eijkelenburg, Natasha K. A. ; Van der Sluis, Inge M. ; Dors, Natasja ; Van den Bos, Cor ; Tissing, Wim J. E. ; Kaspers, Gertjan J. L. ; Van Litsenburg, Raphaële R. L.</creator><creatorcontrib>Steur, Lindsay M. H. ; Grootenhuis, Martha A. ; Van Someren, Eus J. W. ; Van Eijkelenburg, Natasha K. A. ; Van der Sluis, Inge M. ; Dors, Natasja ; Van den Bos, Cor ; Tissing, Wim J. E. ; Kaspers, Gertjan J. L. ; Van Litsenburg, Raphaële R. L.</creatorcontrib><description>Objective
To assess sleep problems (prevalence and predictors) in pediatric patients with acute lymphoblastic leukemia (ALL) after the most intensive phase of therapy (induction).
Methods
Patients (≥2 years) treated according to the Dutch ALL‐11 protocol were included. Sleep was measured using parent‐reports and self‐reports (Children's Sleep Habits Questionnaire; CSHQ) and actigraphy. Parental sleep (Medical Outcome Study Sleep Scale) and distress and parenting problems (Distress Thermometer for Parents) were assessed with questionnaires. Z‐scores were calculated for total CSHQ scores using age‐appropriate scores of healthy Dutch children. The prevalence of sleep problems (defined as a Z‐score > 1) in patients with ALL was compared to healthy children (chi‐square tests). Actigraphic sleep estimates were collected in healthy Dutch children (n = 86, 2‐18 years) for comparison with patients (linear regression). Determinants of parent‐reported child sleep (total CSHQ Z‐score) were identified with regression models.
Results
Responses were collected for 124 patients (response rate 67%), comprising 123 parent‐reports, 34 self‐reports, and 69 actigraphy assessments. Parents reported sleep problems in 38.0% of the patients compared to 15.2% in healthy children (P < .001). Patients reported fewer sleep problems themselves: 12.1% compared to 15.8% in healthy children (P = .33). Total time in bed (B (95% CI): 22.89 (9.55‐36.22)) and total sleep time (B (95% CI):16.30 (1.40‐31.19)), as derived from actigraphy, were significantly longer in patients. More parent‐reported child sleep problems were predicted by parenting problems, more parental sleep problems, bedroom sharing, and child's sleep medication use (explained variance: 27.4%).
Conclusions
Systematic monitoring of child and parental sleep and implementation of effective interventions may be a gateway to improve quality of survival in pediatric ALL.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.28165</identifier><identifier>PMID: 31944548</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>actigraphy ; Acute lymphoblastic leukemia ; Children ; Children & youth ; Hematology ; Induction therapy ; Leukemia ; Lymphatic leukemia ; Oncology ; parenting ; Parents & parenting ; Patients ; pediatric ; Pediatrics ; questionnaires ; Regression analysis ; sleep ; Sleep deprivation ; Sleep disorders</subject><ispartof>Pediatric blood & cancer, 2020-04, Vol.67 (4), p.e28165-n/a</ispartof><rights>2020 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2020 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals, Inc.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3885-61721c8d08340931176c247c312951bb993298572f08227ee2f04950cb7fcd643</citedby><cites>FETCH-LOGICAL-c3885-61721c8d08340931176c247c312951bb993298572f08227ee2f04950cb7fcd643</cites><orcidid>0000-0002-5177-030X ; 0000-0001-9101-507X ; 0000-0002-5822-7668 ; 0000-0003-1779-6159 ; 0000-0002-9970-8791 ; 0000-0002-0526-3737 ; 0000-0001-7716-8475 ; 0000-0002-6175-6077</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31944548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steur, Lindsay M. H.</creatorcontrib><creatorcontrib>Grootenhuis, Martha A.</creatorcontrib><creatorcontrib>Van Someren, Eus J. W.</creatorcontrib><creatorcontrib>Van Eijkelenburg, Natasha K. A.</creatorcontrib><creatorcontrib>Van der Sluis, Inge M.</creatorcontrib><creatorcontrib>Dors, Natasja</creatorcontrib><creatorcontrib>Van den Bos, Cor</creatorcontrib><creatorcontrib>Tissing, Wim J. E.</creatorcontrib><creatorcontrib>Kaspers, Gertjan J. L.</creatorcontrib><creatorcontrib>Van Litsenburg, Raphaële R. L.</creatorcontrib><title>High prevalence of parent‐reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy</title><title>Pediatric blood & cancer</title><addtitle>Pediatr Blood Cancer</addtitle><description>Objective
To assess sleep problems (prevalence and predictors) in pediatric patients with acute lymphoblastic leukemia (ALL) after the most intensive phase of therapy (induction).
Methods
Patients (≥2 years) treated according to the Dutch ALL‐11 protocol were included. Sleep was measured using parent‐reports and self‐reports (Children's Sleep Habits Questionnaire; CSHQ) and actigraphy. Parental sleep (Medical Outcome Study Sleep Scale) and distress and parenting problems (Distress Thermometer for Parents) were assessed with questionnaires. Z‐scores were calculated for total CSHQ scores using age‐appropriate scores of healthy Dutch children. The prevalence of sleep problems (defined as a Z‐score > 1) in patients with ALL was compared to healthy children (chi‐square tests). Actigraphic sleep estimates were collected in healthy Dutch children (n = 86, 2‐18 years) for comparison with patients (linear regression). Determinants of parent‐reported child sleep (total CSHQ Z‐score) were identified with regression models.
Results
Responses were collected for 124 patients (response rate 67%), comprising 123 parent‐reports, 34 self‐reports, and 69 actigraphy assessments. Parents reported sleep problems in 38.0% of the patients compared to 15.2% in healthy children (P < .001). Patients reported fewer sleep problems themselves: 12.1% compared to 15.8% in healthy children (P = .33). Total time in bed (B (95% CI): 22.89 (9.55‐36.22)) and total sleep time (B (95% CI):16.30 (1.40‐31.19)), as derived from actigraphy, were significantly longer in patients. More parent‐reported child sleep problems were predicted by parenting problems, more parental sleep problems, bedroom sharing, and child's sleep medication use (explained variance: 27.4%).
Conclusions
Systematic monitoring of child and parental sleep and implementation of effective interventions may be a gateway to improve quality of survival in pediatric ALL.</description><subject>actigraphy</subject><subject>Acute lymphoblastic leukemia</subject><subject>Children</subject><subject>Children & youth</subject><subject>Hematology</subject><subject>Induction therapy</subject><subject>Leukemia</subject><subject>Lymphatic leukemia</subject><subject>Oncology</subject><subject>parenting</subject><subject>Parents & parenting</subject><subject>Patients</subject><subject>pediatric</subject><subject>Pediatrics</subject><subject>questionnaires</subject><subject>Regression analysis</subject><subject>sleep</subject><subject>Sleep deprivation</subject><subject>Sleep disorders</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp10b9O3TAUBnALtQIKDH0BZKkLHS74TxzbY7lqoRJSGWCOHOeEa-okxnZAd6vUF-AZeRJcLmWo1Mln-J1Px_oQ-kjJMSWEnYTWHjNFa7GFdqmoxEIQKt-9zUTvoA8p3RZaE6G20Q6nuqpEpXbR73N3s8Ihwr3xMFrAU4-DiTDmp1-PEcIUM3Q4eYBQ1NR6GBJ2Iw7QOZOjs0VnV3jCDy6vsLFzBuzXQ1gVbFIuwsP8EwZnsOkzxLLdzTa7acR5BdGE9T563xuf4OD13UPX375eLc8XFz_Ovi-_XCwsV0osaioZtaojildEc0plbVklLadMC9q2WnOmlZCsJ4oxCVCGSgtiW9nbrq74Hjra5JaP3M2QcjO4ZMF7M8I0p4ZxrqWmkteFfvqH3k5zHMt1RQmtZM1f1OeNsnFKKULfhOgGE9cNJc2fZprSTPPSTLGHr4lzO0D3Jv9WUcDJBjw4D-v_JzWXp8tN5DPqL5k8</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Steur, Lindsay M. H.</creator><creator>Grootenhuis, Martha A.</creator><creator>Van Someren, Eus J. W.</creator><creator>Van Eijkelenburg, Natasha K. A.</creator><creator>Van der Sluis, Inge M.</creator><creator>Dors, Natasja</creator><creator>Van den Bos, Cor</creator><creator>Tissing, Wim J. E.</creator><creator>Kaspers, Gertjan J. L.</creator><creator>Van Litsenburg, Raphaële R. L.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5177-030X</orcidid><orcidid>https://orcid.org/0000-0001-9101-507X</orcidid><orcidid>https://orcid.org/0000-0002-5822-7668</orcidid><orcidid>https://orcid.org/0000-0003-1779-6159</orcidid><orcidid>https://orcid.org/0000-0002-9970-8791</orcidid><orcidid>https://orcid.org/0000-0002-0526-3737</orcidid><orcidid>https://orcid.org/0000-0001-7716-8475</orcidid><orcidid>https://orcid.org/0000-0002-6175-6077</orcidid></search><sort><creationdate>202004</creationdate><title>High prevalence of parent‐reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy</title><author>Steur, Lindsay M. H. ; Grootenhuis, Martha A. ; Van Someren, Eus J. W. ; Van Eijkelenburg, Natasha K. A. ; Van der Sluis, Inge M. ; Dors, Natasja ; Van den Bos, Cor ; Tissing, Wim J. E. ; Kaspers, Gertjan J. L. ; Van Litsenburg, Raphaële R. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3885-61721c8d08340931176c247c312951bb993298572f08227ee2f04950cb7fcd643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>actigraphy</topic><topic>Acute lymphoblastic leukemia</topic><topic>Children</topic><topic>Children & youth</topic><topic>Hematology</topic><topic>Induction therapy</topic><topic>Leukemia</topic><topic>Lymphatic leukemia</topic><topic>Oncology</topic><topic>parenting</topic><topic>Parents & parenting</topic><topic>Patients</topic><topic>pediatric</topic><topic>Pediatrics</topic><topic>questionnaires</topic><topic>Regression analysis</topic><topic>sleep</topic><topic>Sleep deprivation</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steur, Lindsay M. H.</creatorcontrib><creatorcontrib>Grootenhuis, Martha A.</creatorcontrib><creatorcontrib>Van Someren, Eus J. W.</creatorcontrib><creatorcontrib>Van Eijkelenburg, Natasha K. A.</creatorcontrib><creatorcontrib>Van der Sluis, Inge M.</creatorcontrib><creatorcontrib>Dors, Natasja</creatorcontrib><creatorcontrib>Van den Bos, Cor</creatorcontrib><creatorcontrib>Tissing, Wim J. E.</creatorcontrib><creatorcontrib>Kaspers, Gertjan J. L.</creatorcontrib><creatorcontrib>Van Litsenburg, Raphaële R. L.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley-Blackwell Free Backfiles(OpenAccess)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steur, Lindsay M. H.</au><au>Grootenhuis, Martha A.</au><au>Van Someren, Eus J. W.</au><au>Van Eijkelenburg, Natasha K. A.</au><au>Van der Sluis, Inge M.</au><au>Dors, Natasja</au><au>Van den Bos, Cor</au><au>Tissing, Wim J. E.</au><au>Kaspers, Gertjan J. L.</au><au>Van Litsenburg, Raphaële R. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of parent‐reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr Blood Cancer</addtitle><date>2020-04</date><risdate>2020</risdate><volume>67</volume><issue>4</issue><spage>e28165</spage><epage>n/a</epage><pages>e28165-n/a</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Objective
To assess sleep problems (prevalence and predictors) in pediatric patients with acute lymphoblastic leukemia (ALL) after the most intensive phase of therapy (induction).
Methods
Patients (≥2 years) treated according to the Dutch ALL‐11 protocol were included. Sleep was measured using parent‐reports and self‐reports (Children's Sleep Habits Questionnaire; CSHQ) and actigraphy. Parental sleep (Medical Outcome Study Sleep Scale) and distress and parenting problems (Distress Thermometer for Parents) were assessed with questionnaires. Z‐scores were calculated for total CSHQ scores using age‐appropriate scores of healthy Dutch children. The prevalence of sleep problems (defined as a Z‐score > 1) in patients with ALL was compared to healthy children (chi‐square tests). Actigraphic sleep estimates were collected in healthy Dutch children (n = 86, 2‐18 years) for comparison with patients (linear regression). Determinants of parent‐reported child sleep (total CSHQ Z‐score) were identified with regression models.
Results
Responses were collected for 124 patients (response rate 67%), comprising 123 parent‐reports, 34 self‐reports, and 69 actigraphy assessments. Parents reported sleep problems in 38.0% of the patients compared to 15.2% in healthy children (P < .001). Patients reported fewer sleep problems themselves: 12.1% compared to 15.8% in healthy children (P = .33). Total time in bed (B (95% CI): 22.89 (9.55‐36.22)) and total sleep time (B (95% CI):16.30 (1.40‐31.19)), as derived from actigraphy, were significantly longer in patients. More parent‐reported child sleep problems were predicted by parenting problems, more parental sleep problems, bedroom sharing, and child's sleep medication use (explained variance: 27.4%).
Conclusions
Systematic monitoring of child and parental sleep and implementation of effective interventions may be a gateway to improve quality of survival in pediatric ALL.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31944548</pmid><doi>10.1002/pbc.28165</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5177-030X</orcidid><orcidid>https://orcid.org/0000-0001-9101-507X</orcidid><orcidid>https://orcid.org/0000-0002-5822-7668</orcidid><orcidid>https://orcid.org/0000-0003-1779-6159</orcidid><orcidid>https://orcid.org/0000-0002-9970-8791</orcidid><orcidid>https://orcid.org/0000-0002-0526-3737</orcidid><orcidid>https://orcid.org/0000-0001-7716-8475</orcidid><orcidid>https://orcid.org/0000-0002-6175-6077</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | actigraphy Acute lymphoblastic leukemia Children Children & youth Hematology Induction therapy Leukemia Lymphatic leukemia Oncology parenting Parents & parenting Patients pediatric Pediatrics questionnaires Regression analysis sleep Sleep deprivation Sleep disorders |
| title | High prevalence of parent‐reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy |
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