Influenza vaccination reduces dementia in patients with chronic obstructive pulmonary disease: a nationwide cohort study

This study aimed to explore the protective potential of influenza vaccination against occurrence of dementia in patients with chronic obstructive pulmonary disease (COPD), who are expected to be more vulnerable to influenza infection. This nationwide retrospective cohort study enrolled patients with...

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Bibliographic Details
Published in:Journal of investigative medicine 2020-04, Vol.68 (4), p.838-845
Main Authors: Luo, Ching-Shan, Chi, Ching-Chi, Fang, Yu-Ann, Liu, Ju-Chi, Lee, Kang-Yun
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Cohort analysis
Drug dosages
Health insurance
Health risk assessment
Immunization
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Summary:This study aimed to explore the protective potential of influenza vaccination against occurrence of dementia in patients with chronic obstructive pulmonary disease (COPD), who are expected to be more vulnerable to influenza infection. This nationwide retrospective cohort study enrolled patients with COPD (aged ≥60 years) from 1 January 2001 to 31 December 2012 by using the Taiwan National Health Insurance Research Database. By applying time-dependent Cox proportional hazard model, we used multivariate analysis to calculate the adjusted HR (aHR) with 95% CI of dementia in relation to influenza vaccination among patients with COPD. Besides, patients were partitioned into four groups according to the vaccination number (unvaccinated, 1, 2–3 and ≥4 total vaccinations) to investigate the dose-response effect of vaccinations on the dementia incidence. This cohort study included 19 848 patients with COPD, and 45% of them received influenza vaccination. The aHR of dementia was 0.68 (95% CI: 0.62 to 0.74, p
ISSN:1081-5589
1708-8267
DOI:10.1136/jim-2019-001155