A new and simple scoring system to predict overall survival after irradiation for metastatic spinal cord compression

Purpose To develop a model that predicts survival in patients irradiated for metastatic spinal cord compression (MSCC), hence assisting in the decision between a short and a long-course radiotherapy (RT) regimen. Methods 138 patients diagnosed with MSCC and treated with RT alone were included. Based...

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Bibliographic Details
Published in:Clinical & translational oncology 2020-03, Vol.22 (3), p.440-444
Main Authors: Nenclares, P., Guardado, S., Asiáin, L., Pérez-Escutia, M. Á., Peña, M. C., Bartolomé, A., Ruíz, A., Cabeza, M. Á., Colmenero, M., Gascón, N., Rodríguez, V., Prados, R., D´Ambrosi, R., Pérez-Regadera, J. F.
Format: Article
Language:English
Subjects:
Brief Research Article
Medicine
Medicine & Public Health
Oncology
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Summary:Purpose To develop a model that predicts survival in patients irradiated for metastatic spinal cord compression (MSCC), hence assisting in the decision between a short and a long-course radiotherapy (RT) regimen. Methods 138 patients diagnosed with MSCC and treated with RT alone were included. Based on a multivariate analysis, a scoring system was developed. It included four prognostic variables: age, number of vertebrae, ECOG and histology. Total scores ranged between 14 and 24 points and patients were divided into two groups. Results The 6-month survival rate was 22% for patients with a score of 14–18 points; and 69% for patients with a score of 19–24 points ( P < 0.001). The system exhibits a high specificity and positive predictive value and an appropriate discriminative ability. Conclusions Patients with scores between 19 and 24 points were found to survive longer, thus a long-course RT appears to be more appropriate.
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-019-02144-5