Genetic diversity of HLA system in two populations from Nuevo León, Mexico: Monterrey and rural Nuevo León

• Published in: Human immunology 2020-09, Vol.81 (9), p.516-518
• Main Authors: Barquera, Rodrigo, Bravo-Acevedo, Alicia, Clayton, Stephen, Munguía, Tirzo Jesús Rodríguez, Hernández-Zaragoza, Diana Iraíz, Adalid-Sáinz, Carmen, Arrieta-Bolaños, Esteban, Aquino-Rubio, Guadalupe, González-Martínez, Marisela Del Rocío, Lona-Sánchez, Abraham, Martínez-Álvarez, Julio César, Arrazola-García, María Araceli, Delgado-Aguirre, Héctor, González-Medina, Liliana, Pacheco-Ubaldo, Hanna, Juárez-Barreto, Vicencio, Benítez-Arvizu, Gamaliel, Escareño-Montiel, Néstor, Juárez-de la Cruz, Federico, Jaramillo-Rodríguez, Yolanda, Salgado-Adame, Antonio, Zúñiga, Joaquín, Yunis, Edmond J, Bekker-Méndez, Carolina, Granados, Julio
• Format: Article
• Language: English
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2019.06.003

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 665 Mexicans from the state of Nuevo León living in the city of Monterrey (N = 226) and rural communities (N = 439), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Nuevo León include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nuevo León are Native American (54.53 ± 0.87% by ML; 48.88% of Native American haplotypes) and European (38.67 ± 4.06% by ML; 32.59% of European haplotypes), and a less prominent African genetic component (6.80 ± 4.30% by ML; 8.26% of African haplotypes).