Genetic diversity of HLA system in two populations from Nuevo León, Mexico: Monterrey and rural Nuevo León

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 665 Mexicans from the state of Nuevo León living in the city of Monterrey (N = 226) and rural communities (N = 439), to obtain information regarding allelic and haplotypic frequencies. We find that t...

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Published in:Human immunology 2020-09, Vol.81 (9), p.516-518
Main Authors: Barquera, Rodrigo, Bravo-Acevedo, Alicia, Clayton, Stephen, Munguía, Tirzo Jesús Rodríguez, Hernández-Zaragoza, Diana Iraíz, Adalid-Sáinz, Carmen, Arrieta-Bolaños, Esteban, Aquino-Rubio, Guadalupe, González-Martínez, Marisela Del Rocío, Lona-Sánchez, Abraham, Martínez-Álvarez, Julio César, Arrazola-García, María Araceli, Delgado-Aguirre, Héctor, González-Medina, Liliana, Pacheco-Ubaldo, Hanna, Juárez-Barreto, Vicencio, Benítez-Arvizu, Gamaliel, Escareño-Montiel, Néstor, Juárez-de la Cruz, Federico, Jaramillo-Rodríguez, Yolanda, Salgado-Adame, Antonio, Zúñiga, Joaquín, Yunis, Edmond J, Bekker-Méndez, Carolina, Granados, Julio
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container_issue 9
container_start_page 516
container_title Human immunology
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creator Barquera, Rodrigo
Bravo-Acevedo, Alicia
Clayton, Stephen
Munguía, Tirzo Jesús Rodríguez
Hernández-Zaragoza, Diana Iraíz
Adalid-Sáinz, Carmen
Arrieta-Bolaños, Esteban
Aquino-Rubio, Guadalupe
González-Martínez, Marisela Del Rocío
Lona-Sánchez, Abraham
Martínez-Álvarez, Julio César
Arrazola-García, María Araceli
Delgado-Aguirre, Héctor
González-Medina, Liliana
Pacheco-Ubaldo, Hanna
Juárez-Barreto, Vicencio
Benítez-Arvizu, Gamaliel
Escareño-Montiel, Néstor
Juárez-de la Cruz, Federico
Jaramillo-Rodríguez, Yolanda
Salgado-Adame, Antonio
Zúñiga, Joaquín
Yunis, Edmond J
Bekker-Méndez, Carolina
Granados, Julio
description We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 665 Mexicans from the state of Nuevo León living in the city of Monterrey (N = 226) and rural communities (N = 439), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Nuevo León include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nuevo León are Native American (54.53 ± 0.87% by ML; 48.88% of Native American haplotypes) and European (38.67 ± 4.06% by ML; 32.59% of European haplotypes), and a less prominent African genetic component (6.80 ± 4.30% by ML; 8.26% of African haplotypes).
doi_str_mv 10.1016/j.humimm.2019.06.003
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title Genetic diversity of HLA system in two populations from Nuevo León, Mexico: Monterrey and rural Nuevo León
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