Dosage Counts: Correcting Trisomy-21-Related Phenotypes in Human Organoids and Xenografts

Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experi...

Full description

Saved in:
Bibliographic Details
Published in:Cell stem cell 2019-06, Vol.24 (6), p.835-836
Main Authors: Manley, William F., Anderson, Stewart A.
Format: Article
Language:English
Subjects:
Animals
Chimera
Down Syndrome
Heterografts
Humans
Mice
Oligodendrocyte Transcription Factor 2
Organoids
Phenotype
Trisomy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that provide an opportunity for the development of novel therapeutics. Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that provide an opportunity for the development of novel therapeutics.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2019.05.009