Awareness of Nonalcoholic Fatty Liver Disease Is Increasing but Remains Very Low in a Representative US Cohort

Background Nonalcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in the USA. Interestingly, most patients with NAFLD are unaware of having any liver disease (LD). We aimed to assess the awareness of suspected NAFLD and factors associated with being aware o...

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Bibliographic Details
Published in:Digestive diseases and sciences 2020-04, Vol.65 (4), p.978-986
Main Authors: Singh, Amandeep, Dhaliwal, Amaninder S., Singh, Shailainder, Kumar, Atul, Lopez, Rocio, Gupta, Mohit, Noureddin, Mazen, Carey, William, McCullough, Arthur, Alkhouri, Naim
Format: Article
Language:English
Subjects:
Adults
Alcohol use
Biochemistry
Body mass index
Diabetes
Disease control
Disease prevention
Gastroenterology
Health sciences
Hepatology
Hospitals
Liver diseases
Medicine
Medicine & Public Health
Metabolic syndrome
Nutrition
Oncology
Original Article
Population
Prevention programs
Primary care
Studies
Transplant Surgery
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Summary:Background Nonalcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in the USA. Interestingly, most patients with NAFLD are unaware of having any liver disease (LD). We aimed to assess the awareness of suspected NAFLD and factors associated with being aware of LD. Methods Adult subjects with suspected NAFLD (BMI > 25) with elevated ALT in the absence of secondary causes of LD who participated in the continuous national health and nutrition examination survey (NHANES) during 2001–2016 were identified and analyzed. Trends of NAFLD awareness were then assessed in periods of 4 years each. Multivariable logistic regression analysis was performed to assess factors associated with LD awareness. Results A total of 7033 subjects were included in the final analysis (1731, 1757, 1711, and 1834 subjects for the periods of 2001–2004, 2005–2008, 2009–2012, and 2013–2016, respectively). Over the study duration, an increase in BMI, waist circumference, diabetes, and HbA1c; and a decrease in the number of smokers, platelets count, bilirubin, total cholesterol, and LDL level were noticed ( p  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-019-05700-9