Magnetic Particle Imaging: Current Applications in Biomedical Research

Magnetic particle imaging (MPI) is a new imaging modality with the potential for high‐resolution imaging while retaining the noninvasive nature of other current modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET). It is able to track location and quantities of...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2020-06, Vol.51 (6), p.1659-1668
Main Authors: Talebloo, Nazanin, Gudi, Mithil, Robertson, Neil, Wang, Ping
Format: Article
Language:English
Subjects:
Biomedical materials
Biomedical Research
Iron oxides
Magnetic fields
magnetic particle imaging (MPI)
Magnetic Resonance Imaging
Magnetics
Magnetite Nanoparticles
Medical imaging
molecular imaging
Nanoparticles
Neuroimaging
Oncology
Positron emission
Positron emission tomography
superparamagnetic iron oxide nanoparticles (SPIONs)
Tomography
Tracers
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Summary:Magnetic particle imaging (MPI) is a new imaging modality with the potential for high‐resolution imaging while retaining the noninvasive nature of other current modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET). It is able to track location and quantities of special superparamagnetic iron oxide nanoparticles without tracing any background signal. MPI utilizes the unique, intrinsic aspects of the nanoparticles: how they react in the presence of the magnetic field, and the subsequent turning off of the field. The current group of nanoparticles that are used in MPI are usually commercially available for MRI. Special MPI tracers are in development by many groups that utilize an iron‐oxide core encompassed by various coatings. These tracers would solve the current obstacles by altering the size and material of the nanoparticles to what is required by MPI. In this review, the theory behind and the development of these tracers are discussed. In addition, applications such as cell tracking, oncology imaging, neuroimaging, and vascular imaging, among others, stemming from the implementation of MPI into the standard are discussed. Level of Evidence: 5 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:1659–1668.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.26875