Conserved and nuanced hierarchy of gene regulatory response to hypoxia

A dynamic assembly of nuclear and cytoplasmic processes regulate gene activity. Hypoxic stress and the associated energy crisis activate a plurality of regulatory mechanisms including modulation of chromatin structure, transcriptional activation and post-transcriptional processes. Temporal control o...

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Bibliographic Details
Published in:The New phytologist 2021-01, Vol.229 (1), p.71-78
Main Authors: Lee, Travis A., Bailey-Serres, Julia
Format: Article
Language:English
Subjects:
Cell Nucleus - genetics
Chromatin
chromatin accessibility
Cytoplasm
Energy conservation
ethylene responsive transcription factor
Flooding
Gene Expression Regulation
Genes
Genomes
histone
Hypoxia
Hypoxia - genetics
Macromolecules
nuclear retention
Nuclei (cytology)
Nucleic acids
Plants
Regulatory mechanisms (biology)
Ribonucleic acid
RNA
RNA polymerase II
Stress
Subpopulations
Tansley insight
Transcription
Transcription activation
Transcription Factors
Transcription, Genetic
Transcriptional Activation
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Summary:A dynamic assembly of nuclear and cytoplasmic processes regulate gene activity. Hypoxic stress and the associated energy crisis activate a plurality of regulatory mechanisms including modulation of chromatin structure, transcriptional activation and post-transcriptional processes. Temporal control of genes is associated with specific chromatin modifications and transcription factors. Genome-scale technologies that resolve transcript subpopulations in the nucleus and cytoplasm indicate post-transcriptional processes enable cells to conserve energy, prepare for prolonged stress and accelerate recovery. Moreover, the harboring of gene transcripts associated with growth in the nucleus and macromolecular RNA–protein complexes contributes to the preferential translation of stress-responsive gene transcripts during hypoxia. We discuss evidence of evolutionary variation in integration of nuclear and cytoplasmic processes that may contribute to variations in flooding resilience.
ISSN:0028-646X
1469-8137
DOI:10.1111/nph.16437