Reflectance confocal microscopy may be included as part of the diagnostic algorithm of early‐stage mycosis fungoides

Introduction Reflectance confocal microscopy (RCM), a noninvasive, real‐time technique of computed tomography, has been widely used for pigmentary, inflammatory, and tumor diseases of the skin. Aim Our main purpose was to analyze the consistency between pathological and RCM characteristics of early‐...

Full description

Saved in:
Bibliographic Details
Published in:Skin research and technology 2020-07, Vol.26 (4), p.591-598
Main Authors: Zhu, Mengyan, Yu, Wenzhong, Wang, Ping, Liu, Jiao, Li, Zhao, Dai, Hui, Xu, Ai‐E
Format: Article
Language:English
Subjects:
Algorithms
Biopsy
Computed tomography
Confocal microscopy
Consistency
diagnose
Diagnosis
diagnostic algorithm
Diagnostic systems
Fungal infections
histopathology
Lymphoma
Microscopy
Mycosis
Mycosis fungoides
Reflectance
reflectance confocal microscopy
Skin diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Reflectance confocal microscopy (RCM), a noninvasive, real‐time technique of computed tomography, has been widely used for pigmentary, inflammatory, and tumor diseases of the skin. Aim Our main purpose was to analyze the consistency between pathological and RCM characteristics of early‐stage mycosis fungoides (MF) and the utility of RCM in the diagnosis of early‐stage MF. Methods According to the RCM features of MF in the early stage, the biopsy sites of 40 cases of suspected MF and 20 cases of chronic inflammatory skin diseases clinically were preliminarily located. Histopathologic and immunohistochemical examinations were performed to make a diagnosis based on the diagnostic algorithm proposed by the International Society for Cutaneous Lymphomas. Results Among the 60 patients observed, there were 12 confirming cases of MF, 14 suspecting cases, 6 not completely excluding cases, and 28 eliminating cases according to the diagnostic algorithm, as well as characteristics of RCM were typical in 8 cases, suspected in 16 cases, not excluded in 3 cases, and excluded in 33 cases. The kappa value was 0.769 (P 
ISSN:0909-752X
1600-0846
DOI:10.1111/srt.12840