Ovarian Sertoli cell tumours: practical points

Rarity of Sertoli cell tumours contributes to a low index of suspicion and therefore a thorough knowledge of the clinicopathological and immunological characteristics of such tumours is essential to diagnosis and proper management of the treatment and follow-up. The current narrative review of liter...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2020-01, Vol.70 (1), p.129-133
Main Authors: Gheorghisan-Galateanu, Ancuta-Augustina, Carsote, Mara, Terzea, Dana, Valea, Ana, Ghemigian, Adina
Format: Article
Language:English
Subjects:
Anopheles
Hyperactivity
Immunohistochemistry
Tumors
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Summary:Rarity of Sertoli cell tumours contributes to a low index of suspicion and therefore a thorough knowledge of the clinicopathological and immunological characteristics of such tumours is essential to diagnosis and proper management of the treatment and follow-up. The current narrative review of literature was planned to focus on ovarian Sertoli cell tumours that arise from the sex cords cells, which are typically benign unilateral neoplasia incidentally detected, or associated with hormonal hyperactivity, in women of reproductive age. A priory unpublished case of a 35-year old female is also introduced as the base of discussion Abdominal massrelated syndrome and vaginal bleeding anomalies have been reported. Genetic background, if presented, is mostly related to Peutz-Jeghers syndrome caused by STK11/LKB1 mutation. The tumour displays a microscopic tubular pattern and rarely displays cords or trabecular, retiform, spindles, diffuse or areolar structures. Although immunohistochemistry can be helpful in establishing the diagnosis, the results are sometimes inconclusive and the current results require new research to establish a specific immunological panel.
ISSN:0030-9982
DOI:10.5455/JPMA.1381